Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.56 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.56 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.56 |
| ▸ | P2RY11 | Q96G91 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.53 |
| ▸ | NT5E | P21589 | 1/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HINT1 | P49773 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.47 |
| ▸ | HRAS | P01112 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13224543 | 1.00 | P2RX3 (0.56) | P2RX3P2RX4P2RX2P2RY11ADORA2A | |
| SCHEMBL13224528 | 1.00 | P2RX3 (0.56) | P2RX3P2RX4P2RX2P2RY11ADORA2A | |
| SCHEMBL13770264 | 0.91 | P2RX3 (0.59) | P2RX3P2RX4P2RX2P2RY11DNMT1 | |
| SCHEMBL19158331 | 0.91 | P2RX3 (0.59) | P2RX3P2RX4P2RX2P2RY11DNMT1 | |
| SCHEMBL6758742 | 0.90 | P2RX3 (0.59) | P2RX3P2RX4P2RX2P2RY11NT5E | |
| SCHEMBL15468212 | 0.88 | P2RX3 (0.58) | P2RX3P2RX4P2RX2P2RY11ADORA2A | |
| SCHEMBL10060178 | 0.88 | P2RX3 (0.58) | P2RX3P2RX4P2RX2P2RY11ADORA2A | |
| SCHEMBL10060175 | 0.88 | P2RX3 (0.58) | P2RX3P2RX4P2RX2P2RY11ADORA2A | |
| SCHEMBL1389470 | 0.88 | P2RX3 (0.58) | P2RX3P2RX4P2RX2P2RY11ADORA2A | |
| SCHEMBL15468216 | 0.88 | P2RX3 (0.58) | P2RX3P2RX4P2RX2P2RY11ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216991-A1 | Synthesis of spongosine | BIOVITRUM AB (PUBL) (SE) | 2010-08-26 | — | — | US | claimed |
| EP-1709057-B1 | SYNTHESIS OF SPONGOSINE | CAMBRIDGE BIOTECHNOLOGY LTD (GB) | 2007-12-19 | — | — | EP | claimed |
| EP-1709057-A1 | SYNTHESIS OF SPONGOSINE | Cambridge Biotechnology Ltd (GB) | 2006-10-11 | — | — | EP | claimed |
| WO-2005070947-A1 | SYNTHESIS OF SPONGOSINE | CAMBRIDGE BIOTECHNOLOGY LIMITED (GB) | 2005-08-04 | — | — | WO | claimed |
| US-20100216991-A1 | Synthesis of spongosine | BIOVITRUM AB (PUBL) (SE) | 2010-08-26 | — | — | US | disclosed |
| US-20100216991-A1 | Synthesis of spongosine | BIOVITRUM AB (PUBL) (SE) | 2010-08-26 | — | — | US | disclosed |
| CN-1910194-B | Synthesis of spongosine | CAMBRIDGE BIOTECHNOLOGY LTD | 2010-05-05 | — | — | CN | disclosed |
| EP-1709057-B1 | SYNTHESIS OF SPONGOSINE | CAMBRIDGE BIOTECHNOLOGY LTD (GB) | 2007-12-19 | — | — | EP | disclosed |
| EP-1709057-B1 | SYNTHESIS OF SPONGOSINE | CAMBRIDGE BIOTECHNOLOGY LTD (GB) | 2007-12-19 | — | — | EP | disclosed |
| CN-1910194-A | Synthesis of spongosine | CAMBRIDGE BIOTECHNOLOGY LTD (GB) | 2007-02-07 | — | — | CN | disclosed |
| EP-1709057-A1 | SYNTHESIS OF SPONGOSINE | Cambridge Biotechnology Ltd (GB) | 2006-10-11 | — | — | EP | disclosed |
| EP-1709057-A1 | SYNTHESIS OF SPONGOSINE | Cambridge Biotechnology Ltd (GB) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005070947-A1 | SYNTHESIS OF SPONGOSINE | CAMBRIDGE BIOTECHNOLOGY LIMITED (GB) | 2005-08-04 | — | — | WO | disclosed |
| WO-2005070947-A1 | SYNTHESIS OF SPONGOSINE | CAMBRIDGE BIOTECHNOLOGY LIMITED (GB) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216991-A1 | Synthesis of spongosine | ADAR, RNGTT, RNMT | P2RX3 2602/4885P2RX4 2575/4885P2RX2 2568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.