Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3448427 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EL3MBTL3L3MBTL1GAA | |
| SCHEMBL3450967 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EL3MBTL3L3MBTL1GAA | |
| SCHEMBL24802129 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KDM4EL3MBTL3L3MBTL1GAA | |
| SCHEMBL24204406 | 0.79 | ALDH1A1 (0.45) | ALDH1A1KDM4EL3MBTL3L3MBTL1GAA | |
| SCHEMBL29307355 | 0.76 | GAA (0.44) | ALDH1A1KDM4EGAALMNAMEN1 | |
| SCHEMBL3766167 | 0.76 | SIGMAR1 (0.50) | ALDH1A1KDM4EL3MBTL3L3MBTL1GAA | |
| SCHEMBL24352086 | 0.76 | ALDH1A1 (0.45) | ALDH1A1KDM4EL3MBTL3L3MBTL1GAA | |
| SCHEMBL4678853 | 0.74 | L3MBTL3 (0.50) | ALDH1A1KDM4EL3MBTL3L3MBTL1F10 | |
| SCHEMBL3766239 | 0.74 | KDM4E (0.51) | ALDH1A1KDM4EGAALMNASMN1; SMN2 | |
| SCHEMBL21281275 | 0.73 | KDM4E (0.65) | ALDH1A1KDM4EL3MBTL3L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20060247238-A1 | Cyclic amines | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247238-A1 | Cyclic amines | F12, F11, F2 | ALDH1A1 2056/4885KDM4E 2242/4885L3MBTL3 3721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.