SCHEMBL345210

SCHEMBL345210

COC(=O)c1coc(COC(C)=O)n1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
SLC6A3 Q01959 1/20 0.43
DAGLA Q9Y4D2 1/20 0.40
ALOX5AP P20292 1/20 0.39
FEN1 P39748 1/20 0.39
CACNA1G O43497 5/20 0.38
ALDH1A1 P00352 3/20 0.38
KCNH2 Q12809 2/20 0.37
FBP1 P09467 1/20 0.36
HSD17B10 Q99714 1/20 0.35
NOTUM Q6P988 1/20 0.35
HRH3 Q9Y5N1 1/20 0.34
GSK3B P49841 2/20 0.33
NLRP3 Q96P20 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2113445 0.86 CYP1A2 (0.46) ALDH1A1FBP1HSD17B10NLRP3
SCHEMBL3436248 0.85 SLC6A2 (0.46) SLC6A2SLC6A4SLC6A3DAGLAALOX5AP
SCHEMBL742154 0.84 ALDH1A1 (0.41) SLC6A2SLC6A4SLC6A3ALOX5APFEN1
SCHEMBL13141153 0.83 SLC6A2 (0.44) SLC6A2SLC6A4SLC6A3DAGLAALOX5AP
SCHEMBL2116168 0.80 DAGLA (0.43) SLC6A2SLC6A4SLC6A3DAGLAALOX5AP
SCHEMBL16130104 0.80 DAGLA (0.43) SLC6A2SLC6A4SLC6A3DAGLAALOX5AP
SCHEMBL3436247 0.80 SLC6A2 (0.50) SLC6A2SLC6A4SLC6A3DAGLAALOX5AP
SCHEMBL1974766 0.79 DAGLA (0.42) SLC6A2SLC6A4SLC6A3DAGLAALOX5AP
SCHEMBL2172653 0.79 DAGLA (0.42) SLC6A2SLC6A4SLC6A3DAGLAALOX5AP
SCHEMBL346006 0.79 CACNA1G (0.42) SLC6A2SLC6A4SLC6A3DAGLAALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12319703-B2 Macrocyclic fused pyrazoles as Mcl-1 inhibitors ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) 2025-06-03 US disclosed
CN-112204036-B Macrocyclic fused pyrazoles as MCL-1 inhibitors 苏州亚盛药业有限公司 2022-12-27 CN disclosed
US-20220396587-A1 MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2022-12-15 US disclosed
US-20220396587-A1 MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2022-12-15 US disclosed
EP-3781575-A1 MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS Ascentage Pharma (Suzhou) Co., Ltd. (CN) 2021-02-24 EP disclosed
CN-112204036-A Macrocyclic fused pyrazoles as MCL-1 inhibitors 苏州亚盛药业有限公司 2021-01-08 CN disclosed
WO-2020151738-A1 MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) 2020-07-30 WO disclosed
WO-2020151738-A1 MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) 2020-07-30 WO disclosed
EP-2648724-B1 HYDROXYLATED AMINOTRIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2016-09-21 EP disclosed
EP-2648724-B1 HYDROXYLATED AMINOTRIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2016-09-21 EP disclosed
EP-2649068-A1 OXAZOLYL-METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS Actelion Pharmaceuticals Ltd. (CH) 2013-10-16 EP disclosed
EP-2648724-A1 HYDROXYLATED AMINOTRIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS Actelion Pharmaceuticals Ltd. (CH) 2013-10-16 EP disclosed
US-20130267569-A1 Hydroxylated Aminotriazole Derivatives as ALX Receptor Agonists IDORSIA PHARMACEUTICALS LTD (CH) 2013-10-10 US disclosed
US-20130267569-A1 Hydroxylated Aminotriazole Derivatives as ALX Receptor Agonists IDORSIA PHARMACEUTICALS LTD (CH) 2013-10-10 US disclosed
US-20130267569-A1 Hydroxylated Aminotriazole Derivatives as ALX Receptor Agonists IDORSIA PHARMACEUTICALS LTD (CH) 2013-10-10 US disclosed
US-20130261159-A1 OXAZOLYL-METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS ACTELION PHARMACEUTICALS LTD. (CH) 2013-10-03 US disclosed
WO-2012077049-A1 OXAZOLYL-METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2012-06-14 WO disclosed
WO-2012077051-A1 HYDROXYLATED AMINOTRIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2012-06-14 WO disclosed
WO-2012077051-A1 HYDROXYLATED AMINOTRIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2012-06-14 WO disclosed
US-20120015950-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015950-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF INTS9, CDK8, SCN8A SLC6A2 1466/4885SLC6A4 2056/4885SLC6A3 1117/4885
US-20220396587-A1 MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS MCL1, BCL2A1, BCL2L1 SLC6A2 4823/4885SLC6A4 4611/4885SLC6A3 4496/4885
US-12319703-B2 Macrocyclic fused pyrazoles as Mcl-1 inhibitors MCL1, BCL2A1, BCL2L1 SLC6A2 4755/4885SLC6A4 4487/4885SLC6A3 4117/4885
US-20130267569-A1 Hydroxylated Aminotriazole Derivatives as ALX Receptor Agonists ADORA1, ADORA3, HCAR3 SLC6A2 1047/4885SLC6A4 815/4885SLC6A3 894/4885
US-20130261159-A1 OXAZOLYL-METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS P2RX7, ADORA3, P2RX1 SLC6A2 2642/4885SLC6A4 2360/4885SLC6A3 2115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.