Sugi Predict

Sugi Predict / Compounds / SCHEMBL345230

SCHEMBL345230

SCHEMBL345230

COC(=O)C(CO)NC(=O)OCc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ KYNU Q16719 1/20 0.64
▸ ALDH1A1 P00352 2/20 0.62
▸ ALOX15 P16050 1/20 0.62
▸ CTSK P43235 5/20 0.58
▸ CTSS P25774 4/20 0.56
▸ CTSL P07711 3/20 0.56
▸ CTSB P07858 3/20 0.56
▸ TRPM8 Q7Z2W7 1/20 0.55
▸ THRB P10828 1/20 0.55
▸ CYP2C9 P11712 1/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ HSD17B10 Q99714 1/20 0.55
▸ TACR1 P25103 2/20 0.54
▸ CTRB1 P17538 2/20 0.54
▸ ATM Q13315 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2256830 1.00 KYNU (0.64) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL345229 1.00 KYNU (0.64) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL6831659 0.94 KYNU (0.59) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL1760460 0.94 KYNU (0.59) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL6826924 0.94 KYNU (0.59) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL8053250 0.91 CTSL (0.65) ALDH1A1ALOX15CTSKCTSSCTSL
SCHEMBL2677964 0.91 CTSK (0.57) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL7032185 0.91 CTSK (0.57) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL17446717 0.91 CTSK (0.57) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL13503284 0.89 ALDH1A1 (0.64) KYNUALDH1A1ALOX15CTSKCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111909067-B Organic total synthesis method of D-penicillamine 浙江凯普化工有限公司 2022-03-15 — — CN claimed
CN-111909067-A Organic total synthesis method of D-penicillamine 浙江凯普化工有限公司 2020-11-10 — — CN claimed
US-20250186392-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF TENACIA BIOTECHNOLOGY HONG KONG CO LTD (HK) 2025-06-12 — — US disclosed
US-12167998-B2 Spiro-lactam NMDA receptor modulators and uses thereof TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (CN) 2024-12-17 — — US disclosed
CN-116745283-A Heterocyclic derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2023-09-12 — — CN disclosed
CN-116685576-A Cysteine protease inhibitors and methods of use thereof 美商帕迪斯生物科学公司 2023-09-01 — — CN disclosed
US-20220151992-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) 2022-05-19 — — US disclosed
CN-111909067-B Organic total synthesis method of D-penicillamine 浙江凯普化工有限公司 2022-03-15 — — CN disclosed
CN-113710687-A Cyclopeptide antibiotics 豪夫迈·罗氏有限公司 2021-11-26 — — CN disclosed
US-11077094-B2 Spiro-lactam NMDA receptor modulators and uses thereof APTINYX INC. (US) 2021-08-03 — — US disclosed
CN-111909067-A Organic total synthesis method of D-penicillamine 浙江凯普化工有限公司 2020-11-10 — — CN disclosed
US-20010018538-A1 New process for a phenylthiobutyl-isoquinoline and intermediates therefor HILPERT HANS (CH) 2001-08-30 — — US disclosed
US-6239296-B1 Process for a phenylthiobutyl-isoquinoline and intermediates therefor HOFFMANN-LA ROCHE INC. 2001-05-29 — — US disclosed
US-6130348-A Process for a phenylthiobutyl-isoquinoline and intermediates therefor HOFFMANN-LA ROCHE INC. (US) 2000-10-10 — — US disclosed
EP-0975601-A1 PROCESS FOR MAKING A BUTYLTHIO-ISOQUINOLINE AND INTERMEDIATES THEREFOR F. HOFFMANN-LA ROCHE AG (CH) 2000-02-02 — — EP disclosed
WO-1998045271-A1 PROCESS FOR MAKING A BUTYLTHIO-ISOQUINOLINE AND INTERMEDIATES THEREFOR F. HOFFMAN-LA ROCHE AG (CH) 1998-10-15 — — WO disclosed
US-5665603-A REACTION WITH PHOSPHATE COMPOUND AND THIOCYANATE THE PERKIN-ELMER CORPORATION (US) 1997-09-09 — — US disclosed
US-5618808-A Benzothiazepine and benzoxazepine derivatives as cholecystokinin receptor antagonists PFIZER, INC. (US) 1997-04-08 — — US disclosed
WO-1995003066-A1 SELECTIVE MODIFICATION OF THE CARBOXY THERMINUS OF A PROTEIN PERKIN-ELMER CORPORATION (US) 1995-02-02 — — WO disclosed
WO-1994001421-A1 BENZOTHIAZEPINE AND BENZOXAZEPINE DERIVATIVES AS CHOLECYSTOKININ RECEPTOR ANTAGONISTS PFIZER INC. (US) 1994-01-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250186392-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF GRIN1, GRIN2A, GRIN3A KYNU 184/4885ALDH1A1 2288/4885ALOX15 3719/4885
US-12167998-B2 Spiro-lactam NMDA receptor modulators and uses thereof GRIN1, GRIN2A, GRIN3A KYNU 184/4885ALDH1A1 2288/4885ALOX15 3719/4885
US-20220151992-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF GRIN1, GRIN2A, GRIN3A KYNU 184/4885ALDH1A1 2288/4885ALOX15 3719/4885
US-20010018538-A1 New process for a phenylthiobutyl-isoquinoline and intermediates therefor WEE1, WEE2, CYP4F11 KYNU 1545/4885ALDH1A1 506/4885ALOX15 1211/4885
US-11077094-B2 Spiro-lactam NMDA receptor modulators and uses thereof GRIN1, GRIN2A, GRIN3A KYNU 184/4885ALDH1A1 2288/4885ALOX15 3719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.