Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5515193 | 0.92 | ALDH1A1 (0.55) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7182969 | 0.84 | NPC1 (0.52) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7190397 | 0.84 | GPR84 (0.52) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL27399387 | 0.81 | TSHR (0.42) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3453563 | 0.81 | NPC1 (0.48) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5536062 | 0.81 | RAB9A (0.48) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL20491470 | 0.81 | NPC1 (0.52) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3982676 | 0.79 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL30912172 | 0.79 | SMN1; SMN2 (0.64) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5016641 | 0.79 | SMN1; SMN2 (0.64) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858824-B2 | Aralkyltetrahydropyridines, their preparation and pharmaceutical compositions containing them | SANOFI-AVENTIS (FR) | 2010-12-28 | — | — | US | disclosed |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | SANOFI-AVENTIS (FR) | 2008-04-24 | — | — | US | disclosed |
| US-7326723-B2 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |
| CN-101096337-A | Aralkyl carboxylic acid, preparation method and application thereof | SANOFI SYNTHELABO (FR) | 2008-01-02 | — | — | CN | disclosed |
| CN-100335464-C | Aralkyl-tetrahydro-pyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI SYNTHELABO (FR) | 2007-09-05 | — | — | CN | disclosed |
| EP-1438291-B1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2005-09-07 | — | — | EP | disclosed |
| CN-1571770-A | Aralkyl-tetrahydro-pyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI SYNTHELABO (FR) | 2005-01-26 | — | — | CN | disclosed |
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-01-20 | — | — | US | disclosed |
| EP-1438291-A1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003033466-A1 | ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014795-A1 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same | CYCS, NADK, CYP2F1 | ALDH1A1 2370/4885NPC1 2301/4885RAB9A 1202/4885 |
| US-20080097117-A1 | Aralkyltetrahydropyridines, Their Preparation and Pharmaceutical Compositions Containing Them | CYP3A43, CYCS, CCNY | ALDH1A1 2661/4885NPC1 2082/4885RAB9A 1673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.