Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PNP | P00491 | 2/20 | 0.41 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | PAH | P00439 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18519933 | 0.69 | NOS1 (0.42) | NOS1MAPTPNPQTRT1NOS3 | |
| SCHEMBL8231706 | 0.68 | NOS1 (0.41) | NOS1MAPTPNPQTRT1NOS3 | |
| SCHEMBL3454198 | 0.68 | CYP3A4 (0.36) | MAPTPNPQTRT1DYRK1AHSD17B10 | |
| SCHEMBL3454164 | 0.68 | NOS1 (0.53) | NOS1MAPTPNPNOS3NOS2 | |
| SCHEMBL5342218 | 0.68 | NOS1 (0.41) | NOS1MAPTPNPQTRT1NOS3 | |
| SCHEMBL2523525 | 0.68 | NOS1 (0.53) | NOS1MAPTPNPDYRK1ANOS3 | |
| SCHEMBL142923 | 0.67 | CDK1 (0.40) | MAPTPNPQTRT1DYRK1ACDK1 | |
| SCHEMBL156195 | 0.65 | KDM4E (0.57) | NOS1MAPTPNPNOS3NOS2 | |
| SCHEMBL25592958 | 0.65 | NOS1 (0.50) | NOS1MAPTPNPNOS3NOS2 | |
| Hydrochloric Acid SCHEMBL625929 | 0.64 | KDM4E (0.59) | NOS1MAPTPNPNOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816525-B1 | Process for the preparation of optically pure tetrahydropterins and derivatives, and specifically of optically pure tetrahydrofolic acid and derivatives thereof, by stereospecific hydrogenation | Merck & Cie (CH) | 2010-10-19 | — | — | US | disclosed |
| US-7504095-B2 | 2,10-dioxo,2,12,12-trihydroxy,8-amino-4,4a,5a,6,9,10,11,11a,12,12a-decahydropterino(6',7':5,6)pyrano(2,3-d)-1,3,2-dioxaphosphorin | TECHNISCHE UNIVERSITAET BRAUNSCHWEIG (DE) | 2009-03-17 | — | — | US | disclosed |
| US-20080306263-A1 | Process For The Preparation Of Optically Pure Tetrahydropterins And Derivatives, And Specifically Of Optically Pure Tetrahydrofolic Acid And Derivatives Thereof, By Stereospecific Hydrogenation | MULLER HANS RUDOLF | 2008-12-11 | — | — | US | disclosed |
| CN-100381442-C | Method for producing by stereospecific hydration tetrahydropterins and optically pure derivatives, in particular tetrahydrofolic acid and its optically pure derivatives | EPROVA AG (CH) | 2008-04-16 | — | — | CN | disclosed |
| US-20070037250-A1 | 2,10-dioxo,2,12,12-trihydroxy,8-amino-4,4a,5a,6,9,10,11,11a,12,12a-decahydropterino(6',7':5,6)pyrano(2,3-d)-1,3,2-dioxaphosphorin | PHOENIX TISSUE REPAIR, INC. | 2007-02-15 | — | — | US | disclosed |
| CN-1264842-C | Process for the preparation of optically pure tetrahydropterin and derivatives thereof, in particular optically pure tetrahydrofolic acid and derivatives thereof, by stereoselective hydrogenation | EPROVA AG (CH) | 2006-07-19 | — | — | CN | disclosed |
| CN-1781919-A | Method for producing by stereospecific hydration tetrahydropterins and optically pure derivatives, in particular tetrahydrofolic acid and its optically pure derivatives | EPROVA AG (CH) | 2006-06-07 | — | — | CN | disclosed |
| CN-1360587-A | Process for the preparation of optically pure tetrahydropterin and derivatives thereof, in particular optically pure tetrahydrofolic acid and derivatives thereof, by stereoselective hydrogenation | EPROVA AG (CH) | 2002-07-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306263-A1 | Process For The Preparation Of Optically Pure Tetrahydropterins And Derivatives, And Specifically Of Optically Pure Tetrahydrofolic Acid And Derivatives Thereof, By Stereospecific Hydrogenation | DHFR, MTHFD2, MTHFD1 | NOS1 1234/4885MAPT 1279/4885PNP 1054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.