Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8819953 | 0.74 | SLC9A1 (0.35) | HSD11B1CYP3A4MEN1MAPTKMT2A | |
| SCHEMBL629678 | 0.64 | CYP3A4 (0.40) | HSD11B1CYP3A4MEN1MAPTKMT2A | |
| SCHEMBL19747293 | 0.60 | ADAM17 (0.49) | HSD11B1CYP3A4MEN1KMT2ALMNA | |
| SCHEMBL7371048 | 0.60 | CYP3A4 (0.39) | HSD11B1CYP3A4MEN1MAPTKMT2A | |
| SCHEMBL605319 | 0.58 | MAOA (0.34) | CYP3A4MEN1MAPTKMT2AELANE | |
| SCHEMBL8883781 | 0.58 | HSD11B1 (0.35) | HSD11B1CYP3A4MEN1MAPTKMT2A | |
| SCHEMBL1680374 | 0.58 | ELANE (0.40) | ALDH1A1ELANETSHR | |
| SCHEMBL11482575 | 0.58 | FDFT1 (0.42) | HSD11B1CYP3A4MEN1KMT2ALMNA | |
| SCHEMBL19814600 | 0.58 | MAOA (0.41) | HSD11B1LMNAPTGS1PLA2G10PLA2G2A | |
| SCHEMBL11068061 | 0.58 | FDFT1 (0.42) | HSD11B1CYP3A4MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007143597-A9 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-11-11 | — | — | WO | disclosed |
| EP-2029572-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007143597-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | disclosed |