Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11482575 | 1.00 | FDFT1 (0.42) | FDFT1CRHBPCRHR2HSD11B1CYP3A4 | |
| SCHEMBL28079322 | 0.78 | FDFT1 (0.44) | FDFT1CRHBPCRHR2HSD11B1CYP3A4 | |
| SCHEMBL19458359 | 0.75 | HSD11B1 (0.36) | HSD11B1CYP3A4CES1CES2AKR1B1 | |
| SCHEMBL28603393 | 0.71 | ALDH1A1 (0.38) | HSD11B1CYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL549395 | 0.69 | MMP2 (0.42) | MEN1KMT2A | |
| SCHEMBL6572038 | 0.67 | CRHBP (0.35) | FDFT1CRHBPCRHR2MEN1KMT2A | |
| SCHEMBL8993551 | 0.63 | CRHBP (0.61) | FDFT1CRHBPCRHR2HSD11B1MEN1 | |
| SCHEMBL923461 | 0.63 | MAOA (0.48) | HSD11B1CES1CES2AKR1B1ALDH1A1 | |
| SCHEMBL5665989 | 0.63 | MAOA (0.39) | HSD11B1CYP3A4CES1CES2AKR1B1 | |
| SCHEMBL15321958 | 0.63 | CYP4F2 (0.42) | HSD11B1CYP3A4CES1CES2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4474800-A | PROTEASE INHIBITORS, MUSCULAR DYSTROPHY | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1984-10-02 | — | — | US | disclosed |
| US-4418075-A | INHIBITING CALCIUM ACTIVATED NEUTRALTHIOL PROTEASE, MUSCULAR DYSTROPHY | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1983-11-29 | — | — | US | disclosed |
| US-4382889-A | Epoxysuccinic acid derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1983-05-10 | — | — | US | disclosed |
| US-4333879-A | CALCIUM-ACTIVATED NEUTRAL THIOLPROTEASE INHIBITOR USED IN THE TREATMENT OF MUSCULAR DYSTROPHY | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1982-06-08 | — | — | US | disclosed |