Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | CDK4 | P11802 | 10/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.34 |
| ▸ | CSF1R | P07333 | 8/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3067368 | 0.74 | ALDH1A1 (0.35) | MAPTALDH1A1MEN1KMT2APDE3B | |
| SCHEMBL3454570 | 0.70 | NMT1 (0.33) | — | |
| SCHEMBL3454588 | 0.67 | MAPT (0.34) | MAPTCDK4CDK6CSF1RALDH1A1 | |
| SCHEMBL30273032 | 0.63 | HTR7 (0.39) | MAPTCDK4CDK6CSF1RALDH1A1 | |
| SCHEMBL12160700 | 0.60 | ALDH1A1 (0.53) | MAPTALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL17660600 | 0.60 | CDK1 (0.43) | MAPTCDK4ALDH1A1CCNE1CDK2 | |
| SCHEMBL25775892 | 0.60 | TNKS (0.40) | CDK4CDK6 | |
| SCHEMBL8257783 | 0.59 | CHRM2 (0.43) | MAPTCDK4ALDH1A1HPGDTSHR | |
| SCHEMBL22325019 | 0.59 | HPGD (0.44) | ALDH1A1HPGDTSHRRAB9ANPC1 | |
| SCHEMBL3583604 | 0.59 | HRH3 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166850-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | High Point Pharmaceuticals, LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154126-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-12-18 | — | — | WO | disclosed |