Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 3/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 3/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454494 | 0.81 | GABRA2 (0.33) | PLATHTR6 | |
| SCHEMBL3468776 | 0.79 | OPRD1 (0.48) | — | |
| SCHEMBL3456235 | 0.77 | GPR119 (0.36) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL3067368 | 0.76 | ALDH1A1 (0.35) | — | |
| SCHEMBL3454499 | 0.73 | HTR6 (0.33) | PLATHTR6 | |
| SCHEMBL3454585 | 0.70 | MAPT (0.34) | — | |
| SCHEMBL22324769 | 0.69 | SLC18A3 (0.48) | HTR6 | |
| SCHEMBL3072064 | 0.65 | SYK (0.44) | PLATHTR6 | |
| SCHEMBL3454488 | 0.64 | CNR2 (0.34) | PLATHTR6 | |
| SCHEMBL3454571 | 0.64 | CTSC (0.34) | MMP1MMP2MMP3MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166850-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | High Point Pharmaceuticals, LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154126-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-12-18 | — | — | WO | disclosed |