Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3464719 | 0.83 | MAPT (0.38) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL19139501 | 0.73 | SIGMAR1 (0.48) | LRRK2ADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL3067368 | 0.73 | ALDH1A1 (0.35) | LRRK2MELKSYKCHRM2CHRM4 | |
| SCHEMBL7082120 | 0.71 | ADRB1 (0.63) | ADRB1ADRB2NCF1PLD1HTR3E | |
| SCHEMBL3454499 | 0.70 | HTR6 (0.33) | JAK2 | |
| SCHEMBL3065789 | 0.69 | JAK2 (0.48) | LRRK2MELKJAK2JAK3SYK | |
| Hydrochloric Acid SCHEMBL28769210 | 0.69 | ADRB1 (0.61) | ADRB1ADRB2NCF1PLD1HTR3E | |
| Bromide SCHEMBL6539744 | 0.69 | ADRB1 (0.61) | ADRB1ADRB2NCF1PLD1HTR3E | |
| SCHEMBL10162461 | 0.68 | HTR3A (0.53) | JAK3HTR3AALDH1A1MEN1NPC1 | |
| SCHEMBL22324796 | 0.66 | SIGMAR1 (0.45) | MELKSIGMAR1PIK3CAALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166850-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | High Point Pharmaceuticals, LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154126-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-12-18 | — | — | WO | disclosed |