Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CCR9 | P51686 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346879 | 0.82 | CSNK2A2 (0.38) | HPGDRAD52KMT2APOLBMEN1 | |
| SCHEMBL2012127 | 0.75 | NPY5R (0.44) | CCR2HPGDRAD52KMT2APOLB | |
| SCHEMBL346784 | 0.71 | MAPT (0.35) | CCR2POLBLMNACYP3A4CYP2C9 | |
| SCHEMBL347208 | 0.70 | MAPT (0.45) | CCR2KMT2A | |
| SCHEMBL11286560 | 0.68 | BRPF1 (0.50) | HPGDKMT2AMEN1MAPK1 | |
| SCHEMBL17477618 | 0.66 | HPGD (0.41) | HPGDKMT2APOLBLMNACYP2C19 | |
| SCHEMBL4414547 | 0.66 | HPGD (0.60) | HPGDPOLBMAPK1 | |
| SCHEMBL29143300 | 0.65 | HTR6 (0.44) | CCR2KMT2APOLBMEN1LMNA | |
| SCHEMBL5040066 | 0.65 | HTR6 (0.47) | CCR2HPGDKMT2APOLBMEN1 | |
| SCHEMBL19837233 | 0.65 | HDAC1 (0.41) | CCR2HPGDRXFP1LMNAHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015977-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2012-01-19 | — | — | US | claimed |
| EP-2387562-A1 | Quinolinone derivatives useful for the treatment of cns disorders | NeuroSearch A/S (DK) | 2011-11-23 | — | — | EP | claimed |
| WO-2010081900-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2010-07-22 | — | — | WO | claimed |
| US-20120015977-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2012-01-19 | — | — | US | disclosed |
| EP-2387562-A1 | Quinolinone derivatives useful for the treatment of cns disorders | NeuroSearch A/S (DK) | 2011-11-23 | — | — | EP | disclosed |
| WO-2010081900-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015977-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | AQP4, PMP22, CHRNA2 | CCR2 300/4885HPGD 1322/4885RAD52 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.