Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363675 | 0.82 | MAPK8 (0.67) | KMT2ASMN1; SMN2 | |
| SCHEMBL7911632 | 0.81 | ALDH1A1 (0.77) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3454285 | 0.81 | ALDH1A1 (0.61) | KMT2AALDH1A1GAAMAPTRAB9A | |
| SCHEMBL5214807 | 0.79 | ALDH1A1 (0.65) | KMT2AALDH1A1GAAMAPTRAB9A | |
| SCHEMBL5094162 | 0.79 | ALDH1A1 (0.60) | KMT2AALDH1A1GAARAB9A | |
| SCHEMBL5215974 | 0.79 | ALDH1A1 (0.61) | KMT2AALDH1A1GAAMAPTPDE10A | |
| SCHEMBL4086210 | 0.77 | MAPK8 (0.64) | KMT2ASMN1; SMN2 | |
| SCHEMBL4165132 | 0.77 | RAB9A (0.74) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4600567 | 0.77 | KMT2A (0.82) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5215442 | 0.77 | ALDH1A1 (0.62) | KMT2AALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |