SCHEMBL345657

SCHEMBL345657

O=c1c(O)c(-c2cccc(O)c2)oc2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 12/20 1.00
KMT2A Q03164 12/20 1.00
KDM4E B2RXH2 12/20 1.00
CYP3A4 P08684 11/20 1.00
MAPT P10636 11/20 1.00
HSD17B10 Q99714 9/20 1.00
HPGD P15428 6/20 1.00
CYP2C9 P11712 6/20 1.00
ALDH1A1 P00352 6/20 1.00
CYP2D6 P10635 4/20 1.00
CYP2C19 P33261 4/20 1.00
DHFR P00374 1/20 0.78
CYP1A2 P05177 1/20 0.78
KCNH2 Q12809 1/20 0.78
TP53 P04637 9/20 0.74
MAPK1 P28482 6/20 0.74
ALOX15 P16050 5/20 0.74
LMNA P02545 4/20 0.74
PKM P14618 2/20 0.74
CA12 O43570 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Resokaempferol SCHEMBL4728192 0.91 MEN1 (0.82) MEN1KMT2AKDM4ECYP3A4MAPT
SCHEMBL31675772 0.88 MEN1 (0.81) MEN1KMT2AKDM4ECYP3A4MAPT
SCHEMBL1628821 0.88 DHFR (1.00) MEN1KMT2AKDM4ECYP3A4MAPT
SCHEMBL344155 0.88 MEN1 (0.81) MEN1KMT2AKDM4ECYP3A4MAPT
Flavonol SCHEMBL27595696 0.88 KDM4E (0.90) MEN1KMT2AKDM4ECYP3A4MAPT
Flavonol SCHEMBL20246 0.85 KDM4E (1.00) MEN1KMT2AKDM4ECYP3A4MAPT
Flavonol SCHEMBL1679068 0.85 KDM4E (1.00) MEN1KMT2AKDM4ECYP3A4MAPT
Flavonol SCHEMBL29433939 0.85 KDM4E (1.00) MEN1KMT2AKDM4ECYP3A4MAPT
SCHEMBL15676318 0.85 KDM4E (0.74) MEN1KMT2AKDM4ECYP3A4MAPT
SCHEMBL30807185 0.85 KDM4E (0.74) MEN1KMT2AKDM4ECYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220249431-A1 ANTIMYCOTIC Karl-Franzens-Universität Graz (AT) 2022-08-11 US claimed
EP-4003522-A1 ANTIMYCOTIC Karl-Franzens-Universität Graz (AT) 2022-06-01 EP claimed
WO-2021013931-A1 ANTIMYCOTIC Karl-Franzens-Universität Graz (AT) 2021-01-28 WO claimed
EP-3769815-A1 ANTIMYCOTIC Karl-Franzens-Universität Graz (AT) 2021-01-27 EP claimed
US-7897637-B2 Methods of using flavonoids to enhance memory THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2011-03-01 US claimed
WO-2008011538-A2 METHODS OF USING FLAVONOIDS TO ENHANCE MEMORY THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2008-01-24 WO claimed
US-20080021096-A1 METHODS OF USING FLAVONOIDS TO ENHANCE MEMORY THE SALK INSTITUTE FOR BIOLOGICAL STUDIES 2008-01-24 US claimed
WO-2006030322-A2 USE OF FLA VONE/FLA VANONE DERIVATIVES FN THE TREATMENT OR PREVENTION OF RESPIRATORY CONDITIONS UNIVERSITY OF MANITOBA (CA) 2006-03-23 WO claimed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
JP-2003504327-A 2003-02-04 JP claimed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 EP claimed
WO-2001080855-A1 TELOMERASE INHIBITORS AND METHODS OF THEIR USE GERON CORPORATION (US) 2001-11-01 WO claimed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO claimed
US-20250263774-A1 DISCOVERING NEW XENOBIOTIC SUBSTRATES OF AN UDP-GLYCOSYLTRANSFERASE WITH A HIGH-THROUGHPUT METHOD UNIV NORTH TEXAS (US) 2025-08-21 US disclosed
US-20220249431-A1 ANTIMYCOTIC Karl-Franzens-Universität Graz (AT) 2022-08-11 US disclosed
EP-4003522-A1 ANTIMYCOTIC Karl-Franzens-Universität Graz (AT) 2022-06-01 EP disclosed
US-20030125264-A1 Methods For Treating Wounds KIMBERLY-CLARK WORLDWIDE, INC. 2003-07-03 US disclosed
US-6555523-B1 Such as 3',4'-diacetoxy-5,6,7-trimethoxyflavone or naringin in the treatment HIV, picornavirus, and/or respiratory virus CASCADE ESTATES LTD. (MU) 2003-04-29 US disclosed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 EP disclosed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080021096-A1 METHODS OF USING FLAVONOIDS TO ENHANCE MEMORY FOS, CREBBP, CREB1 MEN1 3520/4885KMT2A 1152/4885KDM4E 338/4885
US-20220249431-A1 ANTIMYCOTIC ETF1, FOXM1, RIF1 MEN1 1320/4885KMT2A 3803/4885KDM4E 1705/4885
US-20030125264-A1 Methods For Treating Wounds FGF2, MMP1, FIBP MEN1 3867/4885KMT2A 4306/4885KDM4E 2309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.