Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 3/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 10/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | USP14 | P54578 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457875 | 0.87 | NAMPT (0.51) | ADAM10MMP2NAMPTHRH2HRH1 | |
| SCHEMBL3457201 | 0.85 | ADAM10 (0.44) | ADAM10MMP2CDK9CCNT1NAMPT | |
| SCHEMBL6359772 | 0.78 | NAMPT (0.42) | ADAM10MMP2NAMPTJAK1KDM1A | |
| SCHEMBL3457923 | 0.77 | SMN1; SMN2 (0.41) | ADAM10MMP2CDK9CCNT1HRH2 | |
| SCHEMBL3457329 | 0.75 | KDM1A (0.40) | USP5USP14USP7KDM1ACYP11B1 | |
| SCHEMBL3457001 | 0.75 | ALDH1A1 (0.43) | ADAM10MMP2CDK9CCNT1HRH2 | |
| SCHEMBL2174268 | 0.75 | ADAM10 (0.59) | ADAM10MMP2 | |
| SCHEMBL2176159 | 0.75 | ADAM10 (0.59) | ADAM10MMP2 | |
| SCHEMBL3436692 | 0.74 | CCNT1 (0.44) | CDK9CCNT1NAMPT | |
| SCHEMBL5320102 | 0.72 | PDK4 (0.53) | NAMPTJAK1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |