Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 11/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457331 | 0.85 | ADAM10 (0.45) | ADAM10MMP2CDK9CCNT1NAMPT | |
| SCHEMBL3457875 | 0.80 | NAMPT (0.51) | ADAM10MMP2EGLN1NAMPTKDM4E | |
| SCHEMBL6359772 | 0.74 | NAMPT (0.42) | ADAM10MMP2NAMPTCYP11B1CYP11B2 | |
| SCHEMBL3457001 | 0.74 | ALDH1A1 (0.43) | ADAM10MMP2CDK9CCNT1EGLN1 | |
| SCHEMBL3457923 | 0.74 | SMN1; SMN2 (0.41) | ADAM10MMP2CDK9CCNT1EGLN1 | |
| SCHEMBL3436692 | 0.72 | CCNT1 (0.44) | CDK9CCNT1NAMPTKDM4E | |
| SCHEMBL5320102 | 0.69 | PDK4 (0.53) | NAMPT | |
| SCHEMBL3435568 | 0.67 | CCNT1 (0.41) | CDK9CCNT1NAMPT | |
| SCHEMBL3457605 | 0.66 | ADAM10 (0.39) | ADAM10MMP2EGLN1CYP11B1CYP11B2 | |
| SCHEMBL3436504 | 0.64 | CDK9 (0.53) | CDK9CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |