Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457001 | 0.87 | ALDH1A1 (0.43) | SMN1; SMN2KMT2AALDH1A1ADAM10MMP2 | |
| SCHEMBL3457331 | 0.77 | ADAM10 (0.45) | ADAM10MMP2CCNT1CDK9HRH2 | |
| SCHEMBL2173252 | 0.77 | ADAM10 (0.49) | ADAM10MMP2 | |
| SCHEMBL3457850 | 0.77 | ADAM10 (0.46) | ADAM10MMP2EGLN1 | |
| SCHEMBL3457875 | 0.76 | NAMPT (0.51) | ALDH1A1ADAM10MMP2KDM4EEGLN1 | |
| SCHEMBL6359772 | 0.74 | NAMPT (0.42) | ADAM10MMP2HRH2HRH1 | |
| SCHEMBL3457201 | 0.74 | ADAM10 (0.44) | ALDH1A1ADAM10MMP2KDM4EEGLN1 | |
| SCHEMBL3436692 | 0.72 | CCNT1 (0.44) | SMN1; SMN2KMT2AKDM4EMAPTCCNT1 | |
| SCHEMBL3457605 | 0.70 | ADAM10 (0.39) | ADAM10MMP2EGLN1HRH2HRH1 | |
| SCHEMBL5320102 | 0.69 | PDK4 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |