Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | MMP14 | P50281 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BID | P55957 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.41 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14534848 | 0.87 | MMP2 (0.60) | MMP2MMP7MMP14HSD11B1FFAR1 | |
| SCHEMBL30633557 | 0.84 | POLB (0.49) | ATMEGFRERBB2BRD4HSD11B1 | |
| SCHEMBL3904766 | 0.84 | ALDH1A1 (0.50) | ATMEGFRERBB2BRD4CA12 | |
| SCHEMBL28538179 | 0.83 | HSD11B1 (0.56) | ATMBRD4HSD11B1CA12CA9 | |
| SCHEMBL30209492 | 0.83 | HSD11B1 (0.56) | ATMBRD4HSD11B1CA12CA9 | |
| SCHEMBL21872042 | 0.83 | ATM (0.61) | ATMEGFRERBB2BRD4HSD11B1 | |
| SCHEMBL6421436 | 0.83 | ATM (0.42) | ATMMMP2MMP7MMP14EGFR | |
| SCHEMBL10639234 | 0.82 | MMP2 (0.49) | ATMMMP2MMP7MMP14HSD11B1 | |
| SCHEMBL2069136 | 0.80 | ATM (0.48) | ATMEGFRERBB2BRD4HSD11B1 | |
| SCHEMBL21872095 | 0.80 | ATM (0.58) | ATMEGFRERBB2BRD4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115357-A1 | LIVER X RECEPTORS (LXR) MODULATORS | PHENEX-FXR GMBH (DE) | 2020-04-16 | — | — | US | disclosed |
| EP-3609880-A1 | LIVER X RECEPTORS (LXR) MODULATORS | Phenex-FXR GmbH (DE) | 2020-02-19 | — | — | EP | disclosed |
| CN-110546144-A | Liver X Receptor (LXR) modulators | PHENEX FXR GMBH | 2019-12-06 | — | — | CN | disclosed |
| WO-2018188795-A1 | LIVER X RECEPTORS (LXR) MODULATORS | PHENEX-FXR GMBH (DE) | 2018-10-18 | — | — | WO | disclosed |
| CN-1938273-B | Tetrahydrocarbazoles and derivatives | HOFFMAN-LA ROCHE LTD. (CH) | 2011-12-14 | — | — | CN | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| CN-1938273-A | Tetrahydrocarbazoles and derivatives | HOFFMANN LA ROCHE (CH) | 2007-03-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | ATM 3934/4885MMP2 1633/4885MMP7 604/4885 |
| US-20200115357-A1 | LIVER X RECEPTORS (LXR) MODULATORS | NR1H2, NR1H3, NR1H4 | ATM 3280/4885MMP2 4733/4885MMP7 4643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.