Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052487 | 0.84 | APLNR (0.54) | APLNRTDP1GAAMEN1KMT2A | |
| SCHEMBL10087239 | 0.82 | APLNR (0.53) | APLNRTDP1GAAMEN1KMT2A | |
| SCHEMBL14258516 | 0.82 | APLNR (0.53) | APLNRTDP1GAAMEN1KMT2A | |
| SCHEMBL470134 | 0.82 | APLNR (0.53) | APLNRTDP1GAAMEN1KMT2A | |
| SCHEMBL31626613 | 0.82 | APLNR (0.53) | APLNRTDP1GAAMEN1KMT2A | |
| SCHEMBL15684322 | 0.81 | APLNR (0.51) | APLNRGAAMEN1KMT2AMAPK1 | |
| SCHEMBL19136211 | 0.81 | APLNR (0.56) | APLNRTDP1GAAMEN1KMT2A | |
| SCHEMBL284141 | 0.80 | APLNR (0.55) | APLNRTDP1GAAMEN1KMT2A | |
| SCHEMBL29139522 | 0.79 | APLNR (0.50) | APLNRTDP1GAAMEN1KMT2A | |
| SCHEMBL27732646 | 0.79 | APLNR (0.54) | APLNRGAAMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010148300-A1 | METHODS OF TREATMENT OF NEUROLOGICAL DISORDERS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-12-23 | — | — | WO | disclosed |
| EP-1264836-B1 | Processes for the preparation of indolopyrrolocarbazole derivatives | BANYU PHARMA CO LTD (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-0760375-B1 | ANTITUMOR INDOLOPYPROLOCARBAZOLE DERIVATIVE | BANYU PHARMA CO LTD (JP) | 2003-11-26 | — | — | EP | disclosed |
| EP-1264836-A1 | Processes for the preparation of indolopyrrolocarbazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2002-12-11 | — | — | EP | disclosed |
| US-5922860-A | Antitumor indolopyrrolocarbazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-07-13 | — | — | US | disclosed |
| US-5804564-A | Antitumor indolopyrrolocarbazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-09-08 | — | — | US | disclosed |
| US-5668271-A | Indolopyrrolocarbazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-09-16 | — | — | US | disclosed |
| EP-0760375-A1 | ANTITUMOR INDOLOPYPROLOCARBAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-5591842-A | ANTICARCINOGENIC AGENTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |