Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223282 | 0.79 | NPC1 (0.47) | NPC1RAB9ANOTUMTSHRTP53 | |
| SCHEMBL344372 | 0.79 | NPC1 (0.46) | NPC1RAB9ANOTUMTSHRTP53 | |
| SCHEMBL8631839 | 0.79 | RAB9A (0.43) | NPC1RAB9ATP53SMN1; SMN2HSD17B10 | |
| SCHEMBL209522 | 0.79 | RAB9A (0.54) | NPC1RAB9ANOTUMTP53SMN1; SMN2 | |
| SCHEMBL5945926 | 0.79 | NPC1 (0.44) | NPC1RAB9ANOTUMSMN1; SMN2HSD17B10 | |
| SCHEMBL2360245 | 0.75 | NPC1 (0.50) | NPC1RAB9ANOTUMTSHRTP53 | |
| SCHEMBL3621627 | 0.75 | APP (0.50) | NPC1RAB9ANOTUMTSHRTP53 | |
| SCHEMBL345944 | 0.75 | NPC1 (0.51) | NPC1RAB9ANOTUMTP53SMN1; SMN2 | |
| SCHEMBL11219018 | 0.75 | NOTUM (0.53) | NPC1NOTUMMAOAMAOB | |
| SCHEMBL3620750 | 0.74 | NOTUM (0.48) | NOTUMSMN1; SMN2ACHEHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180327396-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-11-15 | — | — | US | claimed |
| US-20160376262-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-12-29 | — | — | US | claimed |
| JP-3880051-B2 | — | — | 2007-02-14 | — | — | JP | claimed |
| US-7138400-B2 | Sulfamides as gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-21 | — | — | US | claimed |
| EP-1334085-B1 | SULFAMIDES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME (GB) | 2005-08-24 | — | — | EP | claimed |
| JP-2004513108-A | — | — | 2004-04-30 | — | — | JP | claimed |
| US-20040049038-A1 | Sulfamides as gamma-secretase inhibitors | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2004-03-11 | — | — | US | claimed |
| EP-1334085-A1 | SULFAMIDES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME LTD. (GB) | 2003-08-13 | — | — | EP | claimed |
| WO-2002036555-A1 | SULFAMIDES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME LIMITED (GB) | 2002-05-10 | — | — | WO | claimed |
| EP-3573611-B1 | AMIDE COMPOUNDS AND USE THEREOF | ALPHALA CO LTD (TW) | 2022-01-12 | — | — | EP | disclosed |
| CN-110846675-B | Synthetic method of 2- (5-aryl-1, 3, 4-oxadiazole-2-yl) aniline compound | 阜阳师范大学 | 2021-05-28 | — | — | CN | disclosed |
| CN-110846675-A | Synthetic method of 2- (5-aryl-1, 3, 4-oxadiazole-2-yl) aniline compound | 阜阳师范大学 | 2020-02-28 | — | — | CN | disclosed |
| US-20180327396-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-11-15 | — | — | US | disclosed |
| US-20160376262-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-12-29 | — | — | US | disclosed |
| US-RE35754-E | FOR TREATING BACTERIAL INFECTIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-24 | — | — | US | disclosed |
| US-5710146-A | ANTIBIOTICS FOR BACTERICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| US-5089490-A | Cephem derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-18 | — | — | US | disclosed |
| US-4758556-A | Cephem derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-07-19 | — | — | US | disclosed |
| US-4399131-A | Cephem derivatives | HOECHST AG (DE) | 1983-08-16 | — | — | US | disclosed |
| US-4278793-A | ANTIBIOTICS, BACTERICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040049038-A1 | Sulfamides as gamma-secretase inhibitors | BACE1, BACE2, PSEN1 | NPC1 2360/4885RAB9A 3262/4885NOTUM 411/4885 |
| US-20180327396-A1 | NOVEL PYRIDINE DERIVATIVES | NDUFS6, NDUFS4, NDUFV1 | NPC1 1807/4885RAB9A 2378/4885NOTUM 3969/4885 |
| US-20160376262-A1 | NOVEL PYRIDINE DERIVATIVES | NDUFS6, NDUFS4, NDUFV1 | NPC1 1807/4885RAB9A 2378/4885NOTUM 3969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.