Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.55 |
| ▸ | GHSR | Q92847 | 3/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128252 | 0.78 | HTR6 (0.51) | HTR6GHSRDRD1ALDH1A1TP53 | |
| SCHEMBL125776 | 0.76 | GHSR (0.43) | HTR6GHSR | |
| SCHEMBL27945955 | 0.72 | HTR6 (0.45) | HTR6GHSRDRD1ALDH1A1TP53 | |
| SCHEMBL3857601 | 0.71 | HTR6 (1.00) | HTR6DRD1 | |
| SCHEMBL3459638 | 0.70 | GHSR (0.46) | HTR6GHSRALDH1A1TP53MAPT | |
| SCHEMBL5981551 | 0.68 | ALDH1A1 (0.47) | HTR6GHSRDRD1ALDH1A1TP53 | |
| SCHEMBL7467988 | 0.67 | MAPT (0.41) | HTR6DRD1ALDH1A1MAPT | |
| SCHEMBL6180564 | 0.66 | ALDH1A1 (0.46) | HTR6GHSRDRD1ALDH1A1TP53 | |
| SCHEMBL125679 | 0.66 | AHR (0.40) | HTR6GHSRDRD1ALDH1A1TP53 | |
| SCHEMBL128573 | 0.66 | ALDH1A1 (0.44) | HTR6GHSRDRD1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103443076-B | Indol-2-one derivatives disubstituted in position 3, their preparation and their therapeutic application | 赛诺菲-安万特 | 2016-06-22 | — | — | CN | disclosed |
| CN-103443076-A | Indol-2-one derivatives disubstituted in position 3, their preparation and their therapeutic application | SANOFI AVENTIS | 2013-12-11 | — | — | CN | disclosed |
| US-8202871-B2 | Indol-2-one derivatives disubstituted in the 3-position, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2012-06-19 | — | — | US | disclosed |
| US-20100210662-A1 | INDOL-2-ONE DERIVATIVES DISUBSTITUTED IN THE 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-19 | — | — | US | disclosed |
| EP-2188253-A2 | INDOL-2-ONE DERIVATIVES DISUBSTITUTED IN THE 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009056707-A2 | INDOL-2-ONE DERIVATIVES DISUBSTITUTED IN THE 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210662-A1 | INDOL-2-ONE DERIVATIVES DISUBSTITUTED IN THE 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | IDO2, IDO1, TPH2 | HTR6 18/4885GHSR 2882/4885DRD1 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.