Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | XDH | P47989 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.56 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.46 |
| ▸ | ABAT | P80404 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515878 | 0.89 | XDH (0.55) | KMT2AMEN1MAPTALDH1A1KDM4C | |
| SCHEMBL1515748 | 0.85 | XDH (0.54) | KMT2AMEN1MAPTALDH1A1KDM4C | |
| SCHEMBL359433 | 0.84 | XDH (0.56) | KMT2AMEN1MAPTALDH1A1KDM4C | |
| SCHEMBL28497425 | 0.84 | ALDH1A1 (0.46) | KMT2AMEN1MAPTALDH1A1KDM4C | |
| SCHEMBL344482 | 0.83 | EGFR (0.66) | KMT2AMEN1MAPTALDH1A1XDH | |
| SCHEMBL29672623 | 0.83 | EGFR (0.66) | KMT2AMEN1MAPTALDH1A1XDH | |
| SCHEMBL374530 | 0.83 | EGFR (0.66) | KMT2AMEN1MAPTALDH1A1XDH | |
| SCHEMBL1515795 | 0.82 | XDH (0.51) | KMT2AMEN1MAPTALDH1A1KDM4C | |
| SCHEMBL1748385 | 0.82 | ALDH1A1 (0.48) | KMT2AMEN1MAPTALDH1A1KDM4C | |
| SCHEMBL1515912 | 0.82 | MAPT (0.45) | KMT2AMEN1MAPTALDH1A1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782559-B1 | NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | ORIONYHTYMAE OY (FI) | 1999-01-13 | — | — | EP | claimed |
| US-5710343-A | Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde | ORION-YHTYMA OY (FI) | 1998-01-20 | — | — | US | claimed |
| EP-0782559-A1 | NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | ORIONYHTYMÄ OY (FI) | 1997-07-09 | — | — | EP | claimed |
| WO-1996009274-A1 | NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | Orion-Yhtymä Oy (FI) | 1996-03-28 | — | — | WO | claimed |
| CN-108440340-B | Method for preparing entacapone | 北京伊斯康科技有限公司 | 2022-08-26 | — | — | CN | disclosed |
| US-9283229-B2 | Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors | NIVALIS THERAPEUTICS, INC. (US) | 2016-03-15 | — | — | US | disclosed |
| US-9283213-B2 | Dihydropyridin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors and neurokinin-3 receptor antagonists | NIVALIS THERAPEUTICS, INC. (US) | 2016-03-15 | — | — | US | disclosed |
| EP-2592934-B1 | NOVEL DIHYDROPYRIDIN-2(1H)-ONE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS AND NEUROKININ-3 RECEPTOR ANTAGONISTS | NIVALIS THERAPEUTICS INC (US) | 2015-08-26 | — | — | EP | disclosed |
| US-20150224107-A1 | Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors | N30 PHARMACEUTICALS, LLC | 2015-08-13 | — | — | US | disclosed |
| US-9067893-B2 | Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors | NIVALIS THERAPEUTICS, INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-20150157616-A1 | Novel Dihydropyridin-2(1H)-One Compounds as S-Nitrosoglutathione Reductase Inhibitors and Neurokinin-3 Receptor Antagonists | NIVALIS THERAPEUTICS, INC. | 2015-06-11 | — | — | US | disclosed |
| US-8946434-B2 | Dihydropyridin-2(1H)-one compound as S-nirtosoglutathione reductase inhibitors and neurokinin-3 receptor antagonists | N30 PHARMACEUTICALS, INC. (US) | 2015-02-03 | — | — | US | disclosed |
| EP-0782559-B1 | NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | ORIONYHTYMAE OY (FI) | 1999-01-13 | — | — | EP | disclosed |
| US-5710343-A | Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde | ORION-YHTYMA OY (FI) | 1998-01-20 | — | — | US | disclosed |
| US-5710343-A | Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde | ORION-YHTYMA OY (FI) | 1998-01-20 | — | — | US | disclosed |
| CN-1164852-A | New preparation method of 3, 4-dihydroxy-5-nitrobenzaldehyde | ORION YHTYMAE OY (FI) | 1997-11-12 | — | — | CN | disclosed |
| EP-0782559-A1 | NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | ORIONYHTYMÄ OY (FI) | 1997-07-09 | — | — | EP | disclosed |
| EP-0782559-A1 | NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | ORIONYHTYMÄ OY (FI) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009274-A1 | NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | Orion-Yhtymä Oy (FI) | 1996-03-28 | — | — | WO | disclosed |
| WO-1996009274-A1 | NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | Orion-Yhtymä Oy (FI) | 1996-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150157616-A1 | Novel Dihydropyridin-2(1H)-One Compounds as S-Nitrosoglutathione Reductase Inhibitors and Neurokinin-3 Receptor Antagonists | QDPR, TACR1, TACR2 | KMT2A 2740/4885MEN1 2258/4885MAPT 4294/4885 |
| US-20150224107-A1 | Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors | QDPR, GSR, CBR1 | KMT2A 3962/4885MEN1 3816/4885MAPT 3445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.