SCHEMBL344482

SCHEMBL344482

COc1cc(C=O)cc([N+](=O)[O-])c1O

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 2/20 0.66
XDH P47989 1/20 0.63
MAPT P10636 5/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
POLB P06746 4/20 0.60
TDP1 Q9NUW8 2/20 0.60
JUN P05412 1/20 0.60
GFER P55789 1/20 0.59
MEN1 O00255 4/20 0.55
KMT2A Q03164 4/20 0.55
ERN1 O75460 1/20 0.55
SIRT1 Q96EB6 1/20 0.53
ALDH1A1 P00352 3/20 0.53
KDM4E B2RXH2 1/20 0.53
CYP3A4 P08684 1/20 0.53
ALOX15 P16050 1/20 0.53
PRKDC P78527 1/20 0.53
HSD17B10 Q99714 1/20 0.53
GAA P10253 3/20 0.51
PIM1 P11309 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL374530 1.00 EGFR (0.66) EGFRXDHMAPTSMN1; SMN2POLB
SCHEMBL29672623 1.00 EGFR (0.66) EGFRXDHMAPTSMN1; SMN2POLB
Methyl Alcohol SCHEMBL29087051 0.98 EGFR (0.64) EGFRXDHMAPTSMN1; SMN2POLB
Cyclohexylamine SCHEMBL7798524 0.86 POLB (0.56) EGFRXDHMAPTSMN1; SMN2POLB
SCHEMBL4499495 0.85 JUN (0.62) EGFRXDHMAPTSMN1; SMN2POLB
SCHEMBL4499494 0.85 JUN (0.62) EGFRXDHMAPTSMN1; SMN2POLB
SCHEMBL31337893 0.83 TUBB4A (0.61) EGFRXDHMAPTSMN1; SMN2POLB
SCHEMBL1447403 0.83 TUBB4A (0.61) EGFRXDHMAPTSMN1; SMN2POLB
SCHEMBL1515869 0.83 XDH (0.58) EGFRXDHMAPTSMN1; SMN2POLB
SCHEMBL346053 0.83 KMT2A (0.64) EGFRXDHMAPTSMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 520 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119320325-A Synthesis method of 3, 4-dihydroxy-5-nitrobenzaldehyde 湖南吴赣药业有限公司 2025-01-17 CN claimed
US-11918671-B2 Multi-tone hair dyeing method in three steps HENKEL AG & CO. KGAA (DE) 2024-03-05 US claimed
CN-116655745-B Application of intermediate in preparation of buserelin 杭州湃肽生化科技有限公司 2023-10-13 CN claimed
CN-116497411-A Cyanide-free alkaline silver plating electroplating solution and preparation and application thereof 上海电力大学 2023-07-28 CN claimed
CN-116041258-A Nitrovanillin heterocyclic derivative, preparation method and application thereof 安徽工业大学 2023-05-02 CN claimed
US-11609214-B2 Systems and methods for improving detection accuracy in electronic trace detectors RAPISCAN SYSTEMS, INC. (US) 2023-03-21 US claimed
US-20230031764-A1 MULTI-TONE HAIR DYEING METHOD IN THREE STEPS HENKEL AG & CO. KGAA (DE) 2023-02-02 US claimed
US-20220257483-A1 INCREASING THE STABILITY OF AGENTS FOR TREATING KERATIN MATERIAL HENKEL AG & CO. KGAA (DE) 2022-08-18 US claimed
CN-114746069-A Three-step multi-tone hair dyeing method 汉高股份有限及两合公司 2022-07-12 CN claimed
EP-4003286-A1 INCREASING THE STABILITY OF AGENTS FOR TREATING KERATIN MATERIAL Henkel AG & Co. KGaA (DE) 2022-06-01 EP claimed
WO-2000050406-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES LION BIOSCIENCE AG (DE) 2000-08-31 WO claimed
US-5663029-A DEVELOPMENT OF LATENT IMAGE, TRANSFERRING TO FORM RECORDING SHEETS, COATING A SUBSTRATE USING POLYMERS XEROX CORPORATION (US) 1997-09-02 US claimed
EP-0589948-B1 METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE ORION YHTYMAE OY (FI) 1996-09-04 EP claimed
US-5382699-A Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde ORION-YHTYMA OY (FI) 1995-01-17 US claimed
EP-0589948-A1 METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE. ORION YHTYMAE OY (FI) 1994-04-06 EP claimed
WO-1993000323-A1 METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE Orion-Yhtymä Oy (FI) 1993-01-07 WO claimed
EP-0290442-A4 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS. CHEMEX PHARMACEUTICALS INC (US) 1990-07-03 EP claimed
EP-0290442-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-11-17 EP claimed
WO-1988003805-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-06-02 WO claimed
US-4668237-A VIOLET OR BLUE AMINO NITROBENZENE DYE L'OREAL (FR) 1987-05-26 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220257483-A1 INCREASING THE STABILITY OF AGENTS FOR TREATING KERATIN MATERIAL KRT18, VIM, CDH1 EGFR 1703/4885XDH 4457/4885MAPT 1677/4885
US-11918671-B2 Multi-tone hair dyeing method in three steps TYR, HAO2, HAAO EGFR 1786/4885XDH 1065/4885MAPT 2879/4885
US-20230031764-A1 MULTI-TONE HAIR DYEING METHOD IN THREE STEPS TYR, HAO2, HAAO EGFR 1786/4885XDH 1065/4885MAPT 2879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.