Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | OXER1 | Q8TDS5 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346818 | 0.84 | HTR2A (0.41) | HTR2AHTR2CEGFROXER1LMNA | |
| SCHEMBL2007470 | 0.78 | HTR2A (0.46) | HTR2AHTR2CKDM4EBACE1KMO | |
| Hydrochloric Acid SCHEMBL18168120 | 0.75 | HTR2A (0.47) | HTR2AHTR2CEGFRKMOOXER1 | |
| SCHEMBL346784 | 0.74 | MAPT (0.35) | KDM4EBACE1LMNAL3MBTL1CA12 | |
| SCHEMBL347208 | 0.71 | MAPT (0.45) | KMOOXER1CCR2 | |
| SCHEMBL1312592 | 0.68 | HCAR3 (0.49) | KDM4EBACE1KMO | |
| SCHEMBL347381 | 0.68 | LMNA (0.35) | LMNAL3MBTL1CA12CA1CA2 | |
| SCHEMBL1312334 | 0.68 | HCAR3 (0.49) | KDM4EBACE1KMO | |
| SCHEMBL17610037 | 0.68 | CA12 (0.39) | HTR2AHTR2CKMOOXER1LMNA | |
| SCHEMBL9495685 | 0.67 | DAO (0.43) | HTR2AHTR2CKDM4EKMOOXER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015977-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2012-01-19 | — | — | US | claimed |
| EP-2387562-A1 | Quinolinone derivatives useful for the treatment of cns disorders | NeuroSearch A/S (DK) | 2011-11-23 | — | — | EP | claimed |
| WO-2010081900-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2010-07-22 | — | — | WO | claimed |
| US-20120015977-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2012-01-19 | — | — | US | disclosed |
| EP-2387562-A1 | Quinolinone derivatives useful for the treatment of cns disorders | NeuroSearch A/S (DK) | 2011-11-23 | — | — | EP | disclosed |
| WO-2010081900-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | NEUROSEARCH A/S (DK) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015977-A1 | QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | AQP4, PMP22, CHRNA2 | HTR2A 193/4885HTR2C 129/4885EGFR 4761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.