Known targets — ChEMBL curated mechanism
CA2CA4GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Topiramate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 20/20 | 1.00 |
| ▸ | CA4 known ✓ | P22748 | 7/20 | 1.00 |
| ▸ | CA1 | P00915 | 10/20 | 1.00 |
| ▸ | CA5A | P35218 | 7/20 | 1.00 |
| ▸ | CA7 | P43166 | 7/20 | 1.00 |
| ▸ | CA9 | Q16790 | 7/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 1.00 |
| ▸ | CA12 | O43570 | 2/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 1.00 |
| ▸ | CA6 | P23280 | 1/20 | 1.00 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Topiramate SCHEMBL7859335 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL6341452 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL18898593 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL1274751 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL1534094 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL17343471 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL23468160 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL5637335 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL13575742 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL4980190 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 40781 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122079853-A | N-substituted indoles and other heterocyclic compounds for the treatment of brain diseases | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075467-A | Application of medicine in preventing or treating hydrocephalus | — | 2026-05-26 | — | — | CN | claimed |
| CN-116850183-B | Methods and pharmaceutical compositions for treating myopia | GRAND PHARMA (CHINA) Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-20260137654-A1 | COMPOUNDS AND METHODS FOR TREATING AN EPILEPTIC DISORDER | THE REGENTS OF THE UNIV OF CALIFORNIA (US) | 2026-05-21 | — | — | US | claimed |
| CN-122070133-A | Pharmaceutical compositions containing androgen receptor inhibitors/antagonists, methods and uses | 苏州开拓药业股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122042871-A | Topiramate cleaning chemical residue detection method and kit | 广州汉光药业股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122055435-A | Alcohol beverage with high content of fruit-flavor volatile compounds and low volatile acidity and preparation method thereof | 拜恩洛基2.0有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122031677-A | Leptin receptor agonist antibodies for the treatment of metabolic dysfunction or hypoleptinemia | 瑞泽恩制药公司 | 2026-05-15 | — | — | CN | claimed |
| US-20260131089-A1 | DRUG DELIVERY DEVICES AND METHODS FOR ADMINISTERING SUBSTANCES TO A BODY CAVITY BY HETEROGENOUS AEROSOLIZATION FOR TREATMENT OF BINGE-EATING DISORDERS AND/OR OBESITY | APTARGROUP, INC. (US) | 2026-05-14 | — | — | US | claimed |
| WO-1998000124-A1 | USE OF TOPIRAMATE OR DERIVATIVES THEREOF FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF POSTISCHEMIC NEURODEGENERATION | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-01-08 | — | — | WO | claimed |
| WO-1998000131-A1 | ANTICONVULSANT DERIVATIVES USEFUL IN TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-01-08 | — | — | WO | claimed |
| WO-1998000123-A1 | USE OF TOPIRAMATE OR DERIVATIVES THEREOF FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF MANIC-DEPRESSIVE BIPOLAR DISORDERS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-01-08 | — | — | WO | claimed |
| WO-1998000130-A2 | ANTICONVULSANT SULFAMATE DERIVATIVES USEFUL IN TREATING OBESITY | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-01-08 | — | — | WO | claimed |
| WO-1998000129-A2 | ANTICONVULSANT DERIVATIVES USEFUL IN TREATING PSORIASIS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-01-08 | — | — | WO | claimed |
| WO-1997019950-A1 | TOPIRAMATE IMMUNOASSAY, AS WELL AS ANALOGS AND ANTIBODIES | OXIS INTERNATIONAL, INC. (US) | 1997-06-05 | — | — | WO | claimed |
| US-5387700-A | Reacting alcohol with sulfuryl chloride in toluene in presence of pyridine or triethylamine to form chlorosulfate, reacting with ammonia or amine in tetrahydrofuran to produce sulfamate | MCNEILAB, INC. (US) | 1995-02-07 | — | — | US | claimed |
| EP-0533483-A2 | Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose and (1-methylcyclohexyl)methanol | MCNEILAB, INC. (US) | 1993-03-24 | — | — | EP | claimed |
| EP-0138441-A2 | Anticonvulsant sulfamate derivatives | McNeilab, Inc. (US) | 1985-04-24 | — | — | EP | claimed |
| US-4513006-A | ANTIEPILEPTIC AGENTS; ANTIGLAUCOMA AGENTS | MCNEIL LAB., INC. (US) | 1985-04-23 | — | — | US | claimed |