Known targets — ChEMBL curated mechanism
CA2CA4GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Topiramate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 20/20 | 1.00 |
| ▸ | CA4 known ✓ | P22748 | 7/20 | 1.00 |
| ▸ | CA1 | P00915 | 10/20 | 1.00 |
| ▸ | CA5A | P35218 | 7/20 | 1.00 |
| ▸ | CA7 | P43166 | 7/20 | 1.00 |
| ▸ | CA9 | Q16790 | 7/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 1.00 |
| ▸ | CA12 | O43570 | 2/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 1.00 |
| ▸ | CA6 | P23280 | 1/20 | 1.00 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Topiramate SCHEMBL7859335 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL6341452 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL18898593 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL1274751 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL1534094 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL17343471 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL23468160 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL5637335 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL13575742 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 | |
| Topiramate SCHEMBL34631 | 1.00 | CA2 (1.00) | CA2CA1CA4CA5ACA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351695-B2 | Topiramate salts and compositions comprising and methods of making and using the same | ORTHO-MCNEIL PHARMACEUTICALS, INC. (US) | 2008-04-01 | — | — | US | disclosed |
| US-7351695-B2 | Topiramate salts and compositions comprising and methods of making and using the same | ORTHO-MCNEIL PHARMACEUTICALS, INC. (US) | 2008-04-01 | — | — | US | disclosed |
| US-20040053853-A1 | Topiramate salts and compositions comprising and methods of making and using the same | ORTHO-MCNEILL PHARMACEUTICAL, INC. | 2004-03-18 | — | — | US | disclosed |
| US-6699840-B2 | COMPRISING TOPIRAMATE SODIUM TRIHYDRATE AND MEANS FOR CONTROLLED- OR DELAYED-RELEASE THEREOF | TRANSFORM PHARMACEUTICALS, INC. | 2004-03-02 | — | — | US | disclosed |
| US-20030166581-A1 | Topiramate salts and compositions comprising them | ORTHO-MCNEILL PHARMACEUTICAL, INC. | 2003-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053853-A1 | Topiramate salts and compositions comprising and methods of making and using the same | SCN3A, CACNA1H, KCNQ3 | CA2 207/4885CA4 459/4885CA1 473/4885 |
| US-20030166581-A1 | Topiramate salts and compositions comprising them | SCN3A, SCN1A, KCNQ3 | CA2 234/4885CA4 611/4885CA1 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.