Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 4/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727085 | 1.00 | HTT (0.52) | HTTALDH1A1KDM4ETP53GLA | |
| Hydrochloric Acid SCHEMBL8939931 | 0.97 | HTT (0.50) | HTTALDH1A1KDM4ETP53GLA | |
| SCHEMBL477228 | 0.97 | — | — | |
| Benzene SCHEMBL8030551 | 0.95 | HTT (0.59) | HTTALDH1A1KDM4ETP53GLA | |
| Hydrochloric Acid SCHEMBL11600093 | 0.94 | HTT (0.47) | HTTALDH1A1KDM4ETP53GLA | |
| Benzene SCHEMBL3841909 | 0.92 | HTT (0.55) | HTTALDH1A1KDM4ETP53GLA | |
| SCHEMBL1801925 | 0.92 | — | — | |
| SCHEMBL10879021 | 0.89 | HTT (0.44) | HTTALDH1A1KDM4ETP53GLA | |
| SCHEMBL18124344 | 0.89 | HTT (0.44) | HTTALDH1A1KDM4ETP53GLA | |
| Piperidine SCHEMBL25200840 | 0.87 | HTT (0.43) | HTTALDH1A1KDM4ETP53GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 995 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353109-B2 | Flindersia alkaloids, derivatives and analogs: compositions and methods for producing the same | UNIVERSITY OF HOUSTON SYSTEM (US) | 2016-05-31 | — | — | US | claimed |
| US-9179994-B2 | Implantable film/mesh composite | COVIDIEN LP (US) | 2015-11-10 | — | — | US | claimed |
| US-20150299196-A1 | Flindersia Alkaloids, Derivatives and Analogs: Compositions and Methods for Producing the Same | UNIVERSITY OF HOUSTON SYSTEM (US) | 2015-10-22 | — | — | US | claimed |
| US-9067946-B2 | Flindersia alkaloids, derivatives and analogs: compositions and methods for producing the same | UNIVERSITY OF HOUSTON SYSTEM (US) | 2015-06-30 | — | — | US | claimed |
| US-9005308-B2 | Implantable film/mesh composite for passage of tissue therebetween | COVIDIEN LP (US) | 2015-04-14 | — | — | US | claimed |
| US-8932621-B2 | Implantable film/mesh composite | COVIDIEN LP (US) | 2015-01-13 | — | — | US | claimed |
| US-20140142520-A1 | IMPLANTABLE DEVICES INCLUDING A MESH AND A PIVOTABLE FILM | COVIDIEN LP (US) | 2014-05-22 | — | — | US | claimed |
| EP-2586400-B1 | Implantable film/Mesh composite | COVIDIEN LP (US) | 2014-03-19 | — | — | EP | claimed |
| EP-2586401-B1 | Implantable film/mesh composite | COVIDIEN LP (US) | 2014-03-19 | — | — | EP | claimed |
| US-20130190511-A1 | Flindersia Alkaloids, Derivatives and Analogs: Compositions and Methods for Producing the Same | HOUSTON SYSTEM, UNIVERSITY OF | 2013-07-25 | — | — | US | claimed |
| US-6282837-B1 | Methods of controlling the growth of undesired vegetation with herbicide tolerant plants or plant seeds having altered protoporphyrinogen oxidase activity | NOVARTIS FINANCE CORPORATION | 2001-09-04 | — | — | US | claimed |
| US-20010016956-A1 | Herbicide-tolerant protox genes produced by DNA shuffling | WARD ERIC R (US) | 2001-08-23 | — | — | US | claimed |
| WO-2001012825-A1 | HERBICIDE-TOLERANT PROTOPORPHYRINOGEN OXIDASE | SYNGENTA PARTICIPATIONS AG (CH) | 2001-02-22 | — | — | WO | claimed |
| US-5939602-A | GENETICALLY ENGINEERED PLANTS EXPRESSING HERBICIDE TOLERANT PROTOX ENZYMES | NOVARTIS FINANCE CORPORATION (US) | 1999-08-17 | — | — | US | claimed |
| EP-0883682-A1 | DNA MOLECULES ENCODING PLANT PROTOPORPHYRINOGEN OXIDASE AND INHIBITOR-RESISTANT MUTANTS THEREOF | Novartis AG (CH) | 1998-12-16 | — | — | EP | claimed |
| WO-1997032011-A1 | DNA MOLECULES ENCODING PLANT PROTOPORPHYRINOGEN OXIDASE AND INHIBITOR-RESISTANT MUTANTS THEREOF | NOVARTIS AG (CH) | 1997-09-04 | — | — | WO | claimed |
| EP-0769059-A1 | MANIPULATION OF PROTOPORPHYRINOGEN OXIDASE ENZYME ACTIVITY IN EUKARYOTIC ORGANISMS | Novartis AG (CH) | 1997-04-23 | — | — | EP | claimed |
| US-5480989-A | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-02 | — | — | US | claimed |
| WO-1995034659-A1 | MANIPULATION OF PROTOPORPHYRINOGEN OXIDASE ENZYME ACTIVITY IN EUKARYOTIC ORGANISMS | CIBA-GEIGY AG (CH) | 1995-12-21 | — | — | WO | claimed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190511-A1 | Flindersia Alkaloids, Derivatives and Analogs: Compositions and Methods for Producing the Same | NAAA, MAOA, AANAT | HTT 480/4885ALDH1A1 2072/4885KDM4E 1971/4885 |
| US-20150299196-A1 | Flindersia Alkaloids, Derivatives and Analogs: Compositions and Methods for Producing the Same | MAOA, NAAA, FLNA | HTT 472/4885ALDH1A1 2383/4885KDM4E 1977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.