Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 12/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 11/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | PTPRS | Q13332 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 9/20 | 0.37 |
| ▸ | MMP1 | P03956 | 4/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3466770 | 0.90 | MMP13 (0.45) | MMP13MMP12MMP2ADAMTS4PTPN2 | |
| SCHEMBL3467062 | 0.85 | MMP13 (0.43) | MMP13MMP12MMP2ADAMTS4PTPN2 | |
| SCHEMBL3467263 | 0.83 | PTPN2 (0.39) | MMP13MMP12ADAMTS4PTPN2PTPN1 | |
| SCHEMBL1859570 | 0.80 | MMP13 (0.38) | MMP13MMP2MMP3MMP1MMP9 | |
| SCHEMBL1861012 | 0.79 | TP53 (0.37) | MMP13MMP2MMP3MMP1MMP9 | |
| SCHEMBL1861139 | 0.78 | ALDH1A1 (0.36) | MMP13MMP2MMP3MMP1MMP9 | |
| SCHEMBL3470074 | 0.76 | STAT3 (0.43) | MMP13MMP12ADAMTS4PTPN2PTPN1 | |
| SCHEMBL3469957 | 0.76 | PTPN2 (0.40) | MMP13MMP12ADAMTS4PTPN2PTPN1 | |
| SCHEMBL1855155 | 0.74 | STAT5B (0.37) | MMP13MMP2MMP3CTSSCTSK | |
| SCHEMBL1856286 | 0.73 | KMT2A (0.40) | MMP13MMP12MMP2STAT3MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010070076-A1 | ALKANOIC ACID DERIVATIVES AND THEIR THERAPEUTIC USE AS HDAC INHIBITORS | CRYSTAX PHARMACEUTICALS, S.L. (ES) | 2010-06-24 | — | — | WO | claimed |
| WO-2010070076-A1 | ALKANOIC ACID DERIVATIVES AND THEIR THERAPEUTIC USE AS HDAC INHIBITORS | CRYSTAX PHARMACEUTICALS, S.L. (ES) | 2010-06-24 | — | — | WO | disclosed |