Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | MST1R | Q04912 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467796 | 0.87 | PGR (0.41) | PGRTDP2NTRK1FLT3GSK3B | |
| SCHEMBL3466901 | 0.74 | PGR (0.41) | PGRTDP2AHRJAK2NTRK1 | |
| SCHEMBL7212449 | 0.73 | ESR2 (0.42) | MEN1ALDH1A1KMT2AMAPK1LMNA | |
| SCHEMBL10352638 | 0.72 | CHRM1 (0.36) | MAPK1 | |
| SCHEMBL1900155 | 0.68 | AHR (0.77) | PGRTDP2AHRPDE3BPDE3A | |
| SCHEMBL19899024 | 0.67 | NOTUM (0.39) | DRD2DRD4 | |
| SCHEMBL29073339 | 0.67 | BRD4 (0.40) | TDP2AHRMEN1KMT2AMAPK1 | |
| SCHEMBL57232 | 0.66 | MAP3K14 (0.39) | MEN1KMT2ALMNA | |
| SCHEMBL7866698 | 0.66 | AHR (0.53) | PGRAHRDRD2DRD4MEN1 | |
| SCHEMBL3307966 | 0.66 | KIF11 (0.68) | PGRTDP2AHRJAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | disclosed |