Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 5/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3466804 | 0.87 | PGR (0.40) | PGRMEN1ALDH1A1KMT2APDE3B | |
| SCHEMBL3467479 | 0.75 | ALDH1A1 (0.38) | PGRCREBBPALDH1A1PDE3BPDE3A | |
| SCHEMBL7212449 | 0.72 | ESR2 (0.42) | CREBBPMEN1ALDH1A1KMT2ABRD4 | |
| SCHEMBL1900635 | 0.68 | PDE3B (0.64) | PGRPDE3BPDE3ATDP2CYP11B1 | |
| SCHEMBL4596892 | 0.67 | KIF11 (0.42) | PGRKMT2APDE3BPDE3ATDP2 | |
| SCHEMBL29073339 | 0.66 | BRD4 (0.40) | MEN1KMT2ATDP2BRD4 | |
| SCHEMBL4596404 | 0.66 | KIF11 (0.44) | CYP11B1CYP11B2KIF11 | |
| SCHEMBL3467229 | 0.65 | FFAR1 (0.38) | PGRTDP2 | |
| SCHEMBL3468501 | 0.65 | TDP2 (0.44) | PGRCREBBPTDP2BRD4 | |
| SCHEMBL3466892 | 0.65 | CYP11B1 (0.42) | CYP11B1CYP11B2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | claimed |