Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.71 |
| ▸ | TGM2 | P21980 | 6/20 | 0.71 |
| ▸ | MAOA | P21397 | 7/20 | 0.55 |
| ▸ | MAOB | P27338 | 7/20 | 0.55 |
| ▸ | TDP2 | O95551 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Iodoisatin SCHEMBL75159 | 0.83 | TGM2 (1.00) | CES1TGM2MAOAMAOBCA12 | |
| 5-Iodoisatin SCHEMBL30794223 | 0.83 | TGM2 (1.00) | CES1TGM2MAOAMAOBCA12 | |
| 5-Iodoisatin SCHEMBL1482216 | 0.82 | TGM2 (0.96) | CES1TGM2MAOAMAOBCA12 | |
| 5-Iodoisatin SCHEMBL28515786 | 0.82 | TGM2 (0.96) | CES1TGM2MAOAMAOBCA12 | |
| SCHEMBL22300581 | 0.77 | MAOA (0.50) | CES1TGM2MAOAMAOB | |
| SCHEMBL4192180 | 0.77 | CES1 (0.62) | CES1TGM2MAOAMAOBBCHE | |
| SCHEMBL30398896 | 0.77 | CES1 (0.62) | CES1TGM2MAOAMAOBBCHE | |
| SCHEMBL8557 | 0.75 | CES1 (0.71) | CES1TGM2MAOAMAOBTDP2 | |
| SCHEMBL13564440 | 0.75 | CES1 (0.60) | CES1TGM2MAOAMAOBBCHE | |
| SCHEMBL29494851 | 0.75 | CES1 (1.00) | CES1TGM2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111574426-B | Diamine monomer containing isoindigo structure and black polyimide synthesized by diamine monomer | 湘潭大学 | 2023-06-23 | — | — | CN | claimed |
| CN-115716795-A | Donor-acceptor type compound based on isoindigo derivative, preparation method, molecular lead and molecular electric switch | 华东理工大学 | 2023-02-28 | — | — | CN | claimed |
| CN-108431209-B | Derived and mature hepatocyte types of liver stem cells and uses thereof | 新加坡科技研究局 | 2023-02-10 | — | — | CN | claimed |
| CN-113912609-A | Preparation method of natural alkaloid tryptanthrin and derivative thereof | 江苏大学 | 2022-01-11 | — | — | CN | claimed |
| CN-111574426-A | Diamine monomer containing isoindigo structure and black polyimide synthesized from diamine monomer | 湘潭大学 | 2020-08-25 | — | — | CN | claimed |
| CN-102690226-A | Multi-nitrogen substituted isatin derivative and synthetic method of multi-nitrogen substituted isatin derivative | UNIV GUANGDONG TECHNOLOGY | 2012-09-26 | — | — | CN | claimed |
| CN-113912609-B | Preparation method of natural alkaloid tryptanthrin and derivatives thereof | 江苏大学 | 2024-01-05 | — | — | CN | disclosed |
| CN-115716795-A | Donor-acceptor type compound based on isoindigo derivative, preparation method, molecular lead and molecular electric switch | 华东理工大学 | 2023-02-28 | — | — | CN | disclosed |
| CN-108431209-B | Derived and mature hepatocyte types of liver stem cells and uses thereof | 新加坡科技研究局 | 2023-02-10 | — | — | CN | disclosed |
| EP-4108659-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | Jacobio Pharmaceuticals Co., Ltd. (CN) | 2022-12-28 | — | — | EP | disclosed |
| CN-114539273-A | Novel heterocyclic derivatives useful as SHP2 inhibitors | 北京加科思新药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-109311848-B | Novel heterocyclic derivatives useful as SHP2 inhibitors | 北京加科思新药研发有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-113912609-A | Preparation method of natural alkaloid tryptanthrin and derivative thereof | 江苏大学 | 2022-01-11 | — | — | CN | disclosed |
| US-5604227-A | EXCITATORY AMINO ACID ANTAGONIST; MONO, DI OR TRI-ACETYLATION OR ALKYLATION | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1997-02-18 | — | — | US | disclosed |
| US-5602169-A | USEFUL IN REDUCING NEURONAL DAMAGE DURING ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-02-11 | — | — | US | disclosed |
| US-5599814-A | SUBSTITUTED PYRIDAZINO(4,5-B)QUINOLINES AS ANTAGONISTS OF EXCITATORY AMINO ACIDS | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1997-02-04 | — | — | US | disclosed |
| EP-0747354-A1 | 3-Substituted oxindole derivatives as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0516297-B1 | Pyridazinediones and their use in the treatment of neurological disorders | ZENECA LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| US-5565483-A | ADMINISTERING AS THERAPY FOR ISCHEMIA, CONVULSIONS OR ASTHMA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0516297-A1 | Pyridazinediones and their use in the treatment of neurological disorders | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | disclosed |