Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | CCKAR | P32238 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468115 | 0.89 | KIF11 (0.47) | KIF11FFAR1TDP2ADRB1ADRB3 | |
| SCHEMBL3467348 | 0.87 | KIF11 (0.41) | KIF11FFAR1 | |
| SCHEMBL3468263 | 0.80 | KIF11 (0.53) | KIF11FFAR1TDP2ADRB1ADRB3 | |
| SCHEMBL3308412 | 0.80 | KIF11 (0.53) | KIF11TDP2ADRB1ADRB3CCKAR | |
| SCHEMBL3467503 | 0.80 | KIF11 (0.44) | KIF11FFAR1TDP2ADRB1ADRB3 | |
| SCHEMBL4891219 | 0.79 | KIF11 (0.56) | KIF11FFAR1TDP2ADRB1ADRB3 | |
| SCHEMBL3467592 | 0.77 | KIF11 (0.52) | KIF11DHODHTDP2ADRB1ADRB3 | |
| SCHEMBL4594888 | 0.74 | KIF11 (0.56) | KIF11DHODHTDP2ADRB1ADRB3 | |
| SCHEMBL3467771 | 0.74 | KIF11 (0.48) | KIF11FFAR1TDP2RXRANR1H2 | |
| SCHEMBL3467252 | 0.74 | KIF11 (0.53) | KIF11FFAR1TDP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074807-A1 | 3, 4-DIHYDROQUINOLIN-2 ( 1H ) -ONE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-07-01 | — | — | WO | disclosed |