Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 6/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | MAP2 | P11137 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630355 | 0.75 | IRAK4 (0.41) | GRM2CASP1IRAK4CYP11B2EGLN2 | |
| SCHEMBL3468430 | 0.74 | GRM2 (0.44) | GRM2CASP1KDM1AIRAK4NSD2 | |
| SCHEMBL4929079 | 0.68 | CASP1 (0.49) | GRM2CASP1IRAK4EGLN2PARP1 | |
| SCHEMBL29998593 | 0.68 | GRM2 (0.49) | GRM2KDM1AALDH1A1CYP2A6 | |
| SCHEMBL3713934 | 0.66 | PARP1 (0.50) | GRM2CASP1IRAK4NSD2PARP1 | |
| SCHEMBL6469331 | 0.66 | HTT (0.44) | GRM2CASP1KDM1AIRAK4NSD2 | |
| SCHEMBL2184380 | 0.65 | KIF11 (0.50) | CYP11B2EGLN2MAP4K4ALDH1A1CYP2A6 | |
| SCHEMBL10110951 | 0.65 | ALDH1A1 (0.56) | GRM2KDM1ACYP11B2EGLN2ALDH1A1 | |
| SCHEMBL28045856 | 0.65 | BCAT2 (0.65) | GRM2CASP1IRAK4PARP1PARP15 | |
| SCHEMBL28203104 | 0.65 | CASP1 (0.52) | GRM2CASP1IRAK4NSD2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010085968-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010076034-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-07-08 | — | — | WO | disclosed |