Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31403610 | 0.95 | HRH3 (0.39) | HRH3KDM5BKDM5AHRH4MCHR1 | |
| SCHEMBL31403748 | 0.85 | DHFR (0.40) | HRH3CYP11B2TSHRHRH4CDK2 | |
| SCHEMBL24017222 | 0.81 | NUDT1 (0.35) | HRH3HRH4HTR6MCHR1 | |
| SCHEMBL31403581 | 0.78 | MCHR1 (0.40) | HRH3HRH4MCHR1 | |
| SCHEMBL28260875 | 0.76 | NFE2L2 (0.39) | HRH3KDM5BKDM5ANPC1RAB9A | |
| SCHEMBL26738184 | 0.74 | HTR6 (0.34) | KDM5BKDM5ACYP11B2NPC1RAB9A | |
| SCHEMBL18502898 | 0.72 | CYP11B2 (0.54) | HRH3CYP11B2HRH4CDK2HTR6 | |
| SCHEMBL22606727 | 0.71 | FFAR4 (0.41) | CYP11B2NPC1RAB9ATSHRRECQL | |
| SCHEMBL3188454 | 0.71 | HTR6 (0.38) | CYP11B2HRH4CDK2CCNA2CCNA1 | |
| SCHEMBL482011 | 0.70 | CYP11B2 (0.41) | HRH3CYP11B2HRH4CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072829-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2010-07-01 | — | — | WO | disclosed |