SCHEMBL3469210

SCHEMBL3469210

c1ccc(N(CN(c2ccccn2)c2ccccn2)c2ccccn2)nc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.61
CYP2C19 P33261 1/20 0.61
HDAC1 Q13547 2/20 0.45
HDAC6 Q9UBN7 2/20 0.45
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC5 Q9UQL6 1/20 0.45
KDM4E B2RXH2 2/20 0.42
LMNA P02545 2/20 0.42
ALDH1A1 P00352 2/20 0.42
POLB P06746 2/20 0.42
CYP1A2 P05177 1/20 0.42
CCR1 P32246 1/20 0.42
CCR5 P51681 1/20 0.42
CCR8 P51685 1/20 0.42
METAP1 P53582 1/20 0.42
BLM P54132 1/20 0.42
HIF1A Q16665 1/20 0.42
DOHH Q9BU89 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL57491 0.85 CYP2D6 (0.80) CYP2D6CYP2C19HDAC1HDAC6HDAC3
SCHEMBL1921570 0.81 CYP2D6 (0.62) CYP2D6CYP2C19HDAC1HDAC6HDAC3
SCHEMBL230049 0.78 MAPT (0.64) CYP2D6CYP2C19HDAC1HDAC6ALDH1A1
SCHEMBL30143833 0.78 CYP2D6 (0.69) CYP2D6CYP2C19HDAC1HDAC6HDAC3
SCHEMBL1444229 0.78 CYP2D6 (0.53) CYP2D6CYP2C19HDAC1HDAC6HDAC3
SCHEMBL11701437 0.78 CYP2D6 (0.63) CYP2D6CYP2C19HDAC1HDAC6HDAC3
SCHEMBL31539931 0.78 CYP2D6 (0.63) CYP2D6CYP2C19HDAC1HDAC6HDAC3
SCHEMBL5609247 0.78 ALDH1A1 (0.57) CYP2D6CYP2C19HDAC1HDAC6KDM4E
SCHEMBL229946 0.78 CYP2D6 (0.69) CYP2D6CYP2C19HDAC1HDAC6HDAC3
SCHEMBL13740973 0.76 CYP2D6 (0.52) CYP2D6CYP2C19HDAC1HDAC6HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9458465-B2 Compositions and methods to modulate cell membrane resealing RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2016-10-04 US disclosed
WO-2016109638-A1 COMPOSITIONS AND METHODS TO PREVENT AND REPAIR ACUTE KIDNEY INJURY RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2016-07-07 WO disclosed
EP-2215126-A2 COMPOSITIONS AND METHODS TO MODULATE CELL MEMBRANE RESEALING University Of Medicine And Dentistry Of New Jersey (US) 2010-08-11 EP disclosed
US-20090208473-A1 COMPOSITIONS AND METHODS TO MODULATE CELL MEMBRANE RESEALING RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2009-08-20 US disclosed
WO-2009073808-A2 COMPOSITIONS AND METHODS TO MODULATE CELL MEMBRANE RESEALING UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) 2009-06-11 WO disclosed