Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | TCF4 | P15884 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3096428 | 0.87 | HSD17B10 (0.55) | LMNAMAPTHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL3471108 | 0.87 | L3MBTL1 (0.53) | LMNAMAPTHSD17B10CREBBPALDH1A1 | |
| SCHEMBL3103910 | 0.87 | LMNA (0.45) | LMNAMAPTHSD17B10CREBBPTCF4 | |
| SCHEMBL3469641 | 0.83 | KLKB1 (0.44) | LMNAMAPTHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL3470506 | 0.82 | GAA (0.48) | LMNAMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL3103633 | 0.82 | LMNA (0.46) | LMNAMAPTCREBBPTCF4CTNNB1 | |
| SCHEMBL3097443 | 0.80 | ALDH1A1 (0.55) | LMNAMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL3085851 | 0.79 | LMNA (0.61) | LMNAMAPTHSD17B10CREBBPTCF4 | |
| SCHEMBL3092958 | 0.78 | GRM2 (0.41) | LMNAMAPTHSD17B10CREBBPTCF4 | |
| SCHEMBL949903 | 0.78 | HSD17B10 (0.61) | LMNAMAPTHSD17B10CREBBPTCF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2172450-B9 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2014-10-08 | — | — | EP | disclosed |
| EP-2172450-B1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-10-16 | — | — | EP | disclosed |
| EP-2172450-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-04-07 | — | — | EP | disclosed |