Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 2/20 | 0.46 |
| ▸ | SCD | O00767 | 3/20 | 0.46 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.45 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3096428 | 0.88 | HSD17B10 (0.55) | L3MBTL1POLBTDP1HSD17B10MAPT | |
| SCHEMBL3469650 | 0.87 | LMNA (0.53) | POLBHSD17B10SCD5MAPTHTT | |
| SCHEMBL3469954 | 0.86 | ATM (0.46) | L3MBTL1POLBTDP1HSD17B10SCD5 | |
| SCHEMBL3090818 | 0.86 | L3MBTL1 (0.43) | L3MBTL1POLBTDP1HDAC3HDAC8 | |
| SCHEMBL3470506 | 0.83 | GAA (0.48) | L3MBTL1POLBTDP1HSD17B10MAPT | |
| SCHEMBL3470605 | 0.83 | ERCC5 (0.50) | L3MBTL1SCDSCD5MAPTNPSR1 | |
| SCHEMBL3097443 | 0.83 | ALDH1A1 (0.55) | L3MBTL1SCDSCD5MAPTHTT | |
| SCHEMBL3097169 | 0.83 | ALDH1A1 (0.40) | L3MBTL1POLBTDP1HDAC3HDAC8 | |
| SCHEMBL3469893 | 0.81 | ALDH1A1 (0.48) | L3MBTL1POLBTDP1MAPTNPSR1 | |
| SCHEMBL14706819 | 0.81 | L3MBTL1 (0.56) | L3MBTL1HDAC3HDAC8NCOR2ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2172450-B9 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2014-10-08 | — | — | EP | disclosed |
| EP-2172450-B1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-10-16 | — | — | EP | disclosed |
| EP-2172450-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-04-07 | — | — | EP | disclosed |