Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.65 |
| ▸ | ALDH3A1 | P30838 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13032907 | 0.91 | ALDH3A1 (0.60) | ALOX5ALDH3A1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL29412576 | 0.88 | ALDH3A1 (0.54) | ALOX5ALDH3A1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3470522 | 0.88 | ALDH3A1 (0.54) | ALOX5ALDH3A1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL13077259 | 0.87 | ALDH3A1 (0.57) | ALOX5ALDH3A1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL3470885 | 0.86 | ALDH3A1 (0.56) | ALOX5ALDH3A1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL3472282 | 0.81 | ALDH3A1 (0.62) | ALDH3A1ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL3472693 | 0.80 | ALDH3A1 (0.62) | ALDH3A1ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL3471021 | 0.79 | ALDH3A1 (0.45) | ALOX5ALDH3A1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL3472185 | 0.79 | ALOX5 (1.00) | ALOX5ALDH3A1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL3473099 | 0.78 | ALDH3A1 (0.59) | ALDH3A1ALDH1A1SMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | BUMHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100286220-A1 | HNF4alpha ANTAGONISTS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-11 | — | — | US | disclosed |
| US-20100286220-A1 | HNF4alpha ANTAGONISTS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-11 | — | — | US | disclosed |
| US-20100286220-A1 | HNF4alpha ANTAGONISTS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-11 | — | — | US | disclosed |
| WO-2010127264-A2 | HNF4α ANTAGONISTS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127246-A2 | HNF4 MODULATORS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127264-A2 | HNF4α ANTAGONISTS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | HNF4A, NCOA4, NR4A3 | ALOX5 4598/4885ALDH3A1 865/4885ALDH1A1 810/4885 |
| US-20100286220-A1 | HNF4alpha ANTAGONISTS AND METHODS OF USE | HNF4A, NCOA4, NR1H4 | ALOX5 4783/4885ALDH3A1 530/4885ALDH1A1 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.