Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH3A1 | P30838 | 8/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA3 | P07451 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13032907 | 0.83 | ALDH3A1 (0.60) | ALDH3A1PKMNOD1LMNASMN1; SMN2 | |
| SCHEMBL3473099 | 0.82 | ALDH3A1 (0.59) | ALDH3A1PKMLMNASMN1; SMN2CA12 | |
| SCHEMBL3470253 | 0.81 | ALOX5 (0.65) | ALDH3A1PKMNOD1LMNASMN1; SMN2 | |
| SCHEMBL3470525 | 0.79 | ALDH3A1 (0.57) | ALDH3A1PKMLMNASMN1; SMN2CA12 | |
| SCHEMBL13077259 | 0.79 | ALDH3A1 (0.57) | ALDH3A1PKMNOD1LMNASMN1; SMN2 | |
| SCHEMBL13076785 | 0.78 | ALDH3A1 (0.55) | ALDH3A1PKMNOD1LMNASMN1; SMN2 | |
| SCHEMBL13076783 | 0.78 | ALDH3A1 (0.55) | ALDH3A1PKMNOD1LMNASMN1; SMN2 | |
| SCHEMBL3470817 | 0.78 | ALDH1A1 (0.58) | ALDH3A1PKMNOD1LMNASMN1; SMN2 | |
| SCHEMBL3634978 | 0.72 | SMN1; SMN2 (0.66) | ALDH3A1PKMNOD1LMNASMN1; SMN2 | |
| SCHEMBL22462449 | 0.69 | SMN1; SMN2 (0.66) | ALDH3A1PKMNOD1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | BUMHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | BUMHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | BUMHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-16 | — | — | US | disclosed |
| WO-2010127246-A2 | HNF4 MODULATORS AND METHODS OF USE | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | HNF4A, NCOA4, NR4A3 | ALDH3A1 865/4885PKM 3891/4885NOD1 4161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.