Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3092696 | 0.86 | TRPM8 (0.44) | ALDH1A1LMNANPSR1KDM4EMAPT | |
| SCHEMBL27787105 | 0.82 | ALDH1A1 (0.53) | ALDH1A1LMNANPSR1KDM4EMAPT | |
| SCHEMBL3471108 | 0.81 | L3MBTL1 (0.53) | ALDH1A1LMNANPSR1MAPTSMN1; SMN2 | |
| SCHEMBL2830701 | 0.81 | TSHR (0.57) | ALDH1A1LMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL3083807 | 0.80 | ALDH1A1 (0.43) | ALDH1A1LMNANPSR1KDM4EMAPT | |
| SCHEMBL3096936 | 0.79 | ALDH1A1 (0.49) | ALDH1A1LMNANPSR1KDM4EMAPT | |
| SCHEMBL3470348 | 0.78 | TGM2 (0.47) | ALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL27787082 | 0.76 | ALDH1A1 (0.46) | ALDH1A1LMNANPSR1MAPTSMN1; SMN2 | |
| SCHEMBL15652816 | 0.76 | ALDH1A1 (0.51) | ALDH1A1LMNANPSR1KDM4EMAPT | |
| SCHEMBL3091958 | 0.76 | ALDH1A1 (0.48) | ALDH1A1LMNANPSR1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2172450-B9 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2014-10-08 | — | — | EP | disclosed |
| EP-2172450-B1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-10-16 | — | — | EP | disclosed |
| EP-2172450-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-04-07 | — | — | EP | disclosed |