Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexane SCHEMBL27646533 | 0.98 | NAAA (0.58) | NAAALMNACYP2C19SMN1; SMN2HTT | |
| SCHEMBL22213807 | 0.98 | NAAA (0.58) | NAAALMNACYP2C19SMN1; SMN2HTT | |
| SCHEMBL3472508 | 0.98 | NAAA (0.58) | NAAALMNACYP2C19SMN1; SMN2HTT | |
| SCHEMBL27617118 | 0.96 | NAAA (0.52) | NAAALMNACYP2C19SMN1; SMN2HTT | |
| SCHEMBL19690549 | 0.91 | LMNA (0.47) | NAAALMNACYP2C19SMN1; SMN2HTT | |
| SCHEMBL5071456 | 0.91 | LMNA (0.47) | NAAALMNACYP2C19SMN1; SMN2HTT | |
| SCHEMBL207015 | 0.91 | NAAA (0.64) | NAAALMNACYP2C19SMN1; SMN2HTT | |
| Butane SCHEMBL2857848 | 0.91 | NAAA (0.65) | NAAALMNACYP2C19SMN1; SMN2HTT | |
| SCHEMBL258780 | 0.89 | NAAA (0.66) | NAAALMNACYP2C19SMN1; SMN2HTT | |
| SCHEMBL7568980 | 0.89 | NAAA (0.66) | NAAALMNACYP2C19SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456278-B2 | Lactams substituted by cyclic succinates as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA CORPORATION (US) | 2008-11-25 | — | — | US | claimed |
| US-20080103128-A1 | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF ABETTA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-05-01 | — | — | US | claimed |
| US-20250154181-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2025-05-15 | — | — | US | disclosed |
| US-12173021-B2 | Treprostinil prodrugs | UNITED THERAPEUTICS CORPORATION (US) | 2024-12-24 | — | — | US | disclosed |
| US-20240051979-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2024-02-15 | — | — | US | disclosed |
| US-11634443-B2 | Treprostinil prodrugs | UNITED THERAPEUTICS CORPORATION (US) | 2023-04-25 | — | — | US | disclosed |
| CN-114616225-A | Treprostinil prodrugs | 联合治疗公司 | 2022-06-10 | — | — | CN | disclosed |
| US-8586731-B2 | Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation | SURMODICS, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| CN-102712705-A | Preparation method of solid catalyst for propylene polymerization | SAMSUNG TOTAL PETROCHEMICALS | 2012-10-03 | — | — | CN | disclosed |
| US-20100316687-A1 | HYDROPHOBIC POLYSACCHARIDES WITH DIESTER- OR CARBONATE ESTER-CONTAINING LINKAGES HAVING ENHANCED DEGRADATION | SURMODICS MD, LLC | 2010-12-16 | — | — | US | disclosed |
| CN-101189295-B | Cellulose ester film, polarizing plate and liquid crystal display | KONICA MINOLTA OPTO INC | 2010-12-15 | — | — | CN | disclosed |
| US-7354914-B2 | Lactams substituted by cyclic succinates as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-04-08 | — | — | US | disclosed |
| US-20050261274-A1 | Lactams substituted by cyclic succinates as inhibitors of Abeta protein production | OLSON RICHARD E | 2005-11-24 | — | — | US | disclosed |
| US-6958329-B2 | Lactams substituted by cyclic succinates as inhibitors of A-β protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-10-25 | — | — | US | disclosed |
| US-20030119815-A1 | Lactams substituted by cyclic succinates as inhibitors of A-beta protein production | OLSON RICHARD E (US) | 2003-06-26 | — | — | US | disclosed |
| US-6509333-B2 | Lactams substituted by cyclic succinates as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-01-21 | — | — | US | disclosed |
| EP-1268450-A1 | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| CN-1386118-A | Lactams substituted by cyclic succinates as inhibitors of A beta protein production | BRISTOL MYERS SQUIBB CO (US) | 2002-12-18 | — | — | CN | disclosed |
| US-20020137737-A1 | Lactams substituted by cyclic succinates as inhibitors of a beta protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-09-26 | — | — | US | disclosed |
| WO-2001092235-A1 | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250154181-A1 | TREPROSTINIL PRODRUGS | TYMP, TK1, DCTPP1 | NAAA 178/4885LMNA 3503/4885CYP2C19 44/4885 |
| US-20020137737-A1 | Lactams substituted by cyclic succinates as inhibitors of a beta protein production | APP, BACE1, APH1A | NAAA 264/4885LMNA 1628/4885CYP2C19 1406/4885 |
| US-20050261274-A1 | Lactams substituted by cyclic succinates as inhibitors of Abeta protein production | BACE1, APP, APH1A | NAAA 690/4885LMNA 1656/4885CYP2C19 1601/4885 |
| US-20080103128-A1 | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF ABETTA PROTEIN PRODUCTION | APH1A, APH1B, APP | NAAA 119/4885LMNA 2433/4885CYP2C19 1438/4885 |
| US-20240051979-A1 | TREPROSTINIL PRODRUGS | TYMP, TK1, DCTPP1 | NAAA 178/4885LMNA 3503/4885CYP2C19 44/4885 |
| US-20030119815-A1 | Lactams substituted by cyclic succinates as inhibitors of A-beta protein production | APH1A, APH1B, APP | NAAA 143/4885LMNA 1505/4885CYP2C19 1537/4885 |
| US-20100316687-A1 | HYDROPHOBIC POLYSACCHARIDES WITH DIESTER- OR CARBONATE ESTER-CONTAINING LINKAGES HAVING ENHANCED DEGRADATION | CD44, SI, ENGASE | NAAA 1210/4885LMNA 1409/4885CYP2C19 876/4885 |
| US-12173021-B2 | Treprostinil prodrugs | TYMP, TK1, DCTPP1 | NAAA 178/4885LMNA 3503/4885CYP2C19 44/4885 |
| US-11634443-B2 | Treprostinil prodrugs | TYMP, TK1, DCTPP1 | NAAA 178/4885LMNA 3503/4885CYP2C19 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.