SCHEMBL3473560

SCHEMBL3473560

C[Si](C)(C)Oc1cc[c]c(-c2ccccc2)c1-c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 2/20 0.33
BRD2 P25440 1/20 0.33
PTGS1 P23219 1/20 0.32
PTGS2 P35354 1/20 0.32
TDO2 P48775 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7071376 0.81 PDE4B (0.39)
SCHEMBL15757652 0.73 SCN9A (0.34)
SCHEMBL11802233 0.73 CYP1A2 (0.41) PTGS1PTGS2
SCHEMBL9559577 0.71 NPC1 (0.46)
SCHEMBL7070227 0.71 BRD4 (0.36) BRD4BRD2PTGS1PTGS2TDO2
SCHEMBL29181735 0.70 BRD4 (0.35) BRD4BRD2PTGS1PTGS2TDO2
SCHEMBL3473557 0.70 TDO2 (0.33) BRD4BRD2PTGS1PTGS2TDO2
SCHEMBL9559552 0.70 L3MBTL1 (0.43)
SCHEMBL9559575 0.70 HPGD (0.44)
SCHEMBL7708325 0.69 ALDH1A1 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010149493-A2 COSMETIC COMPOSITION COMPRISING A STYRENE/ACRYLATE COPOLYMER AND A SILICONE RESIN L'OREAL (FR) 2010-12-29 WO disclosed