SCHEMBL3473557

SCHEMBL3473557

C[Si](C)(C)Oc1[c]ccc(-c2ccccc2)c1-c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 2/20 0.33
BRD4 O60885 2/20 0.33
BRD2 P25440 1/20 0.33
PTGS1 P23219 1/20 0.32
PTGS2 P35354 1/20 0.32
PDE4B Q07343 2/20 0.31
PDE4A P27815 1/20 0.31
PDE4C Q08493 1/20 0.31
PDE4D Q08499 1/20 0.31
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7468941 0.81 PDE4B (0.40) PDE4BPDE4APDE4CPDE4D
SCHEMBL17491788 0.77 BACE1 (0.34) PDE4BPDE4APDE4CPDE4D
SCHEMBL7355495 0.74 HPRT1 (0.38) PDE4BPDE4APDE4CPDE4D
SCHEMBL7470694 0.73 SQOR (0.40) PTGS2PDE4BPDE4APDE4CPDE4D
SCHEMBL10415463 0.72 MAPT (0.41) PDE4BPDE4APDE4CPDE4D
SCHEMBL6829533 0.71 CYP2A6 (0.36) TDO2BRD4BRD2PTGS1PTGS2
SCHEMBL3473560 0.70 BRD4 (0.33) TDO2BRD4BRD2PTGS1PTGS2
SCHEMBL7467257 0.69 TOP1 (0.41)
SCHEMBL891578 0.69 LMNA (0.36) PDE4BPDE4APDE4CPDE4DMAOB
SCHEMBL7467196 0.68 PDGFRB (0.35) PTGS1PDE4BPDE4APDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010149493-A2 COSMETIC COMPOSITION COMPRISING A STYRENE/ACRYLATE COPOLYMER AND A SILICONE RESIN L'OREAL (FR) 2010-12-29 WO disclosed