Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Pentobarbital. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.48 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.48 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentobarbital SCHEMBL2688595 | 0.96 | CYP3A4 (0.47) | CYP3A4KDM4EALDH1A1GABRB3OPRD1 | |
| Pentobarbital SCHEMBL16240950 | 0.96 | CYP3A4 (0.47) | CYP3A4KDM4EALDH1A1GABRB3OPRD1 | |
| Pentobarbital SCHEMBL22265808 | 0.95 | CYP3A4 (0.46) | CYP3A4KDM4EALDH1A1GABRB3OPRD1 | |
| Pentobarbital SCHEMBL1419428 | 0.95 | ALDH1A1 (0.49) | CYP3A4KDM4EALDH1A1GABRB3OPRD1 | |
| Pentobarbital SCHEMBL2689394 | 0.94 | CYP3A4 (0.49) | CYP3A4KDM4EALDH1A1GABRB3OPRD1 | |
| Pentobarbital SCHEMBL2769858 | 0.94 | CYP3A4 (0.51) | CYP3A4KDM4EALDH1A1GABRB3OPRD1 | |
| Pentobarbital SCHEMBL22092117 | 0.93 | CYP3A4 (0.44) | CYP3A4KDM4EALDH1A1GABRB3OPRD1 | |
| Pentobarbital SCHEMBL7025367 | 0.93 | ALDH1A1 (0.47) | CYP3A4KDM4EALDH1A1GABRB3OPRD1 | |
| Pentobarbital SCHEMBL2715148 | 0.93 | CYP3A4 (0.48) | CYP3A4KDM4EALDH1A1GABRB3OPRD1 | |
| Pentobarbital SCHEMBL477033 | 0.92 | CYP3A4 (0.50) | CYP3A4KDM4EALDH1A1GABRB3OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118530412-A | Binder for negative electrode, negative electrode slurry, negative electrode, and lithium battery | 深圳好电科技有限公司 | 2024-08-23 | — | — | CN | claimed |
| CN-118530412-A | Binder for negative electrode, negative electrode slurry, negative electrode, and lithium battery | 深圳好电科技有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-109689792-B | Liquid antioxidant composition for raw rubber | 巴斯夫欧洲公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-107099023-B | Diketopyrrolo-pyrrole polymer for organic field effect tube | 巴斯夫欧洲公司 | 2019-10-22 | — | — | CN | disclosed |
| US-10428194-B2 | Modified acrylic resin cured product, and laminate thereof, and production methods therefor | MITSUI CHEMICALS, INC. (JP) | 2019-10-01 | — | — | US | disclosed |
| EP-3263635-B1 | MODIFIED ACRYLIC RESIN CURED PRODUCT, AND LAMINATE THEREOF, AND PRODUCTION METHODS THEREFOR | MITSUI CHEMICALS INC (JP) | 2019-09-18 | — | — | EP | disclosed |
| US-20180163056-A1 | HYDROPHILIC CURABLE COMPOSITIONS | MITSUI CHEMICALS, INC. (JP) | 2018-06-14 | — | — | US | disclosed |
| US-20180036995-A1 | HYDROPHILIC MONOLAYER FILM WITH OPTICAL FUNCTIONALITY AND STACK OF THE SAME | MITSUI CHEMICALS, INC. (JP) | 2018-02-08 | — | — | US | disclosed |
| US-20180030230-A1 | MODIFIED ACRYLIC RESIN CURED PRODUCT, AND LAMINATE THEREOF, AND PRODUCTION METHODS THEREFOR | MITSUI CHEMICALS, INC. (JP) | 2018-02-01 | — | — | US | disclosed |
| EP-3270192-A1 | HYDROPHILIC SINGLE-LAYER FILM HAVING OPTICAL FUNCTIONALITY, AND LAMINATE THEREOF | Mitsui Chemicals, Inc. (JP) | 2018-01-17 | — | — | EP | disclosed |
| EP-3263635-A1 | MODIFIED ACRYLIC RESIN CURED PRODUCT, AND LAMINATE THEREOF, AND PRODUCTION METHODS THEREFOR | Mitsui Chemicals, Inc. (JP) | 2018-01-03 | — | — | EP | disclosed |
| EP-3081578-A1 | COMPOSITION FOR HYDROPHILIC CURED PRODUCT | Mitsui Chemicals, Inc. (JP) | 2016-10-19 | — | — | EP | disclosed |
| US-8586731-B2 | Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation | SURMODICS, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| US-20100316687-A1 | HYDROPHOBIC POLYSACCHARIDES WITH DIESTER- OR CARBONATE ESTER-CONTAINING LINKAGES HAVING ENHANCED DEGRADATION | SURMODICS MD, LLC | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100316687-A1 | HYDROPHOBIC POLYSACCHARIDES WITH DIESTER- OR CARBONATE ESTER-CONTAINING LINKAGES HAVING ENHANCED DEGRADATION | CD44, SI, ENGASE | GABRB3 3846/4885GABRA2 4258/4885GABRB2 3930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.