⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21611735 | 1.00 | — | — | |
| SCHEMBL9654791 | 0.85 | — | — | |
| SCHEMBL4088275 | 0.79 | — | — | |
| SCHEMBL4258104 | 0.75 | NPC1 (0.37) | — | |
| SCHEMBL5706303 | 0.75 | — | — | |
| SCHEMBL1697828 | 0.71 | TRPA1 (0.35) | — | |
| SCHEMBL581261 | 0.69 | NPC1 (0.41) | — | |
| SCHEMBL8444804 | 0.67 | NPC1 (0.34) | — | |
| Rel-Menthone SCHEMBL80559 | 0.67 | NPC1 (0.33) | — | |
| Menthone SCHEMBL80560 | 0.67 | NPC1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10584134-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2020-03-10 | — | — | US | disclosed |
| US-20180093997-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2018-04-05 | — | — | US | disclosed |
| US-9718839-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2017-08-01 | — | — | US | disclosed |
| US-9445606-B2 | Use of 4-hydroxydihydrochalcones and their salts for enhancing an impression of sweetness | SYMRISE AG (DE) | 2016-09-20 | — | — | US | disclosed |
| US-20150086491-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2015-03-26 | — | — | US | disclosed |
| US-8927605-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2015-01-06 | — | — | US | disclosed |
| US-8574554-B2 | Uses of 4-methyl-5-hydroxy-hexanoic acid lactone | SYMRISE AG (DE) | 2013-11-05 | — | — | US | disclosed |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2012-10-18 | — | — | US | disclosed |
| CN-102596157-A | Oral compositions for treatment of dry mouth | PROCTER & GAMBLE | 2012-07-18 | — | — | CN | disclosed |
| EP-1939279-B1 | Skin model | SYMRISE AG (DE) | 2012-07-11 | — | — | EP | disclosed |
| US-20100233102-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2010-09-16 | — | — | US | disclosed |
| EP-1341512-B1 | RHINOLOGICAL AGENTS | SYMRISE GMBH & CO KG (DE) | 2008-12-31 | — | — | EP | disclosed |
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | SYMRISE GMBH & CO. KG (DE) | 2008-10-02 | — | — | US | disclosed |
| US-20080220140-A1 | USE OF PROPENYLPHENYL GLYCOSIDES FOR ENHANCING SWEET SENSORY IMPRESSIONS | SYMRISE GMBH & CO. KG (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20070297993-A1 | Novel Use of Nonenolide | SYMRISE GMBH & CO. KG (DE) | 2007-12-27 | — | — | US | disclosed |
| US-20070254826-A1 | Novel uses of 4-methyl-5-hydroxy-hexanoic acid lactone | SYMRISE GMBH & CO. KG (DE) | 2007-11-01 | — | — | US | disclosed |
| EP-1248532-A1 | AROMAS AND AROMA COMPOSITIONS CONTAINING 4,8-DIMETHYL-3,7-NONADIEN-2-ONE | Symrise GmbH & Co. KG (DE) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001043567-A1 | AROMAS AND AROMA COMPOSITIONS CONTAINING 4,8-DIMETHYL-3,7-NONADIEN-2-ONE, AND A METHOD FOR THE PRODUCTION THEREOF | HAARMANN & REIMER GMBH (DE) | 2001-06-21 | — | — | WO | disclosed |