SCHEMBL3475870

SCHEMBL3475870

C/C=N/N(C)c1cc(=O)[nH]c(=O)[nH]1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 4/20 0.44
CA1 P00915 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.33
ALDH1A1 P00352 2/20 0.33
KDM4E B2RXH2 2/20 0.33
THRB P10828 1/20 0.33
HPGD P15428 1/20 0.33
LMNA P02545 2/20 0.33
CYP1A2 P05177 1/20 0.33
YTHDF3 Q7Z739 1/20 0.32
YTHDF1 Q9BYJ9 1/20 0.32
YTHDF2 Q9Y5A9 1/20 0.32
KDM4C Q9H3R0 2/20 0.32
TAAR1 Q96RJ0 1/20 0.30
APAF1 O14727 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1362732 0.74 GPR84 (0.53) GPR84CA1SMN1; SMN2ALDH1A1LMNA
SCHEMBL28818278 0.72 GPR84 (0.51) GPR84CA1SMN1; SMN2ALDH1A1LMNA
SCHEMBL2182131 0.71 SMN1; SMN2 (0.61) SMN1; SMN2ALDH1A1KDM4ETHRBHPGD
SCHEMBL2181657 0.71 GPR84 (0.50) GPR84CA1SMN1; SMN2ALDH1A1LMNA
SCHEMBL10095166 0.66 GPR84 (0.53) GPR84CA1SMN1; SMN2ALDH1A1LMNA
SCHEMBL3471967 0.65 ALDH1A1 (0.50) SMN1; SMN2ALDH1A1KDM4ETHRBHPGD
SCHEMBL3475882 0.64 TSHR (0.44) SMN1; SMN2ALDH1A1KDM4ETHRBHPGD
SCHEMBL3470000 0.64 HPGD (0.49) SMN1; SMN2ALDH1A1KDM4ETHRBHPGD
SCHEMBL27312293 0.63 GAA (0.46) GPR84CA1ALDH1A1YTHDF3YTHDF1
SCHEMBL14656172 0.62 GPR84 (0.69) GPR84CA1SMN1; SMN2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010072807-A2 INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE FONDATION JEROME LEJEUNE (FR) 2010-07-01 WO disclosed