Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476220 | 0.81 | ALPL (0.33) | KDRPDGFRBALPLTP53HSD17B10 | |
| SCHEMBL2387600 | 0.71 | ALPL (0.38) | KDRPDGFRBALPLKDM4EALDH1A1 | |
| SCHEMBL30900153 | 0.65 | DGAT1 (0.47) | KDM4EGSK3AGSK3BALDH1A1MAPT | |
| SCHEMBL13625129 | 0.63 | PDGFRB (0.40) | KDRPDGFRBALPLTP53HSD17B10 | |
| SCHEMBL21634990 | 0.62 | UCHL1 (0.35) | KDM4ETSHRALDH1A1MAPTLMNA | |
| SCHEMBL23247605 | 0.62 | ALPL (0.48) | KDRPDGFRBALPLEGFRKDM4E | |
| SCHEMBL21672048 | 0.61 | L3MBTL1 (0.44) | KDM4ETSHRGSK3AGSK3BALDH1A1 | |
| SCHEMBL21439053 | 0.61 | LIPG (0.56) | LMNA | |
| SCHEMBL30061503 | 0.61 | LIPG (0.56) | LMNA | |
| SCHEMBL29394284 | 0.61 | L3MBTL1 (0.44) | KDM4ETSHRGSK3AGSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009053737-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | disclosed |