Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475701 | 0.87 | NUDT1 (0.42) | — | |
| SCHEMBL3475816 | 0.82 | HRH4 (0.46) | HTTALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL3477496 | 0.80 | CDK1 (0.39) | HTTCYP3A4MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL3477066 | 0.78 | HRH4 (0.41) | HTTMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL2773622 | 0.77 | HRH4 (0.44) | HTTALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL3477573 | 0.76 | CASP1 (0.41) | HTTLMNAL3MBTL1MAPTTDP1 | |
| SCHEMBL3476221 | 0.76 | SENP6 (0.41) | HTTLMNAL3MBTL1MAPTNPSR1 | |
| SCHEMBL2775160 | 0.76 | HRH4 (0.43) | HTTLMNAMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL2772133 | 0.74 | HRH4 (0.42) | HTTALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL3474881 | 0.74 | CYP2C19 (0.49) | HTTLMNAL3MBTL1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130900-A2 | TRIAMINOPYRIMIDINE DERIVATIVES AS CDC25 PHOSPHATASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-11-18 | — | — | WO | claimed |
| WO-2010130900-A2 | TRIAMINOPYRIMIDINE DERIVATIVES AS CDC25 PHOSPHATASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-11-18 | — | — | WO | disclosed |