SCHEMBL3477385

SCHEMBL3477385

COCc1ccc(-c2ccc3oc(N4C=C5CC=CC=C5C4)nc3c2)cc1

nearest known ligand 0.58

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FAAH O00519 16/20 0.58
GAA P10253 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PIK3CA P42336 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3476685 0.82 FAAH (0.59) FAAHL3MBTL1
SCHEMBL3474913 0.82 FAAH (0.58) FAAH
SCHEMBL3476242 0.80 FAAH (0.44) FAAH
SCHEMBL3476542 0.78 PTGES (0.33) FAAH
SCHEMBL3476078 0.77 FAAH (0.46) FAAH
SCHEMBL13436780 0.74 FAAH (1.00) FAAHGAAL3MBTL1
SCHEMBL3475759 0.63 FAAH (0.57) FAAHGAA
SCHEMBL13436765 0.62 FAAH (0.77) FAAHGAAL3MBTL1
SCHEMBL3476204 0.61 FAAH (1.00) FAAH
SCHEMBL13765046 0.58 MAPT (0.51) FAAHGAAPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010039186-A2 COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF RENOVIS, INC. (US) 2010-04-08 WO disclosed