Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 8/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20562338 | 0.74 | ESR1 (0.35) | ESR1ESR2KDM4EMAPTALDH1A1 | |
| SCHEMBL10934474 | 0.74 | MAPT (0.34) | KDM4EMAPTALDH1A1GAAHTT | |
| SCHEMBL20562476 | 0.74 | POLB (0.42) | ESR1ESR2KDM4EMAPTALDH1A1 | |
| SCHEMBL20563419 | 0.74 | MAPT (0.42) | ESR1ESR2KDM4EMAPTALDH1A1 | |
| SCHEMBL18876006 | 0.74 | CYP2A6 (0.42) | KDM4EMAPTALDH1A1GAAHTT | |
| SCHEMBL31449821 | 0.74 | IMPDH2 (0.37) | CYP3A4KDM4EMAPTTSHRALDH1A1 | |
| SCHEMBL29352476 | 0.72 | KDM4E (0.45) | KDM4EMAPTALDH1A1GAAHTT | |
| SCHEMBL2498909 | 0.72 | KDM4E (0.45) | KDM4EMAPTALDH1A1GAAHTT | |
| SCHEMBL3808419 | 0.72 | TSHR (0.41) | ESR2MAPTTSHRALDH1A1MEN1 | |
| SCHEMBL3810026 | 0.71 | CYP2A6 (0.32) | KDM4EMAPTCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049200-B1 | NOVEL INHIBITORS OF BETA-LACTAMASE | METHYLGENE INC (CA) | 2015-04-29 | — | — | EP | disclosed |
| US-8440643-B2 | Inhibitors of beta-lactamase | METHYLGENE INC. (CA) | 2013-05-14 | — | — | US | disclosed |
| US-8324263-B2 | Microbiocidally active carboxamides | SYNGENTA CROP PROTECTION, LLC (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324263-B2 | Microbiocidally active carboxamides | SYNGENTA CROP PROTECTION, LLC (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100292239-A1 | NOVEL MICROBIOCIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100292239-A1 | NOVEL MICROBIOCIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100279983-A1 | NOVEL INHIBITORS OF BETA-LACTAMASE | METHYLGENE INC. | 2010-11-04 | — | — | US | disclosed |
| EP-2049200-A2 | NOVEL INHIBITORS OF BETA-LACTAMASE | MethylGene Inc. (CA) | 2009-04-22 | — | — | EP | disclosed |
| WO-2009012998-A1 | NOVEL MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-01-29 | — | — | WO | disclosed |
| WO-2008073142-A2 | NOVEL INHIBITORS OF BETA-LACTAMASE | MERCK & CO., INC. (US) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279983-A1 | NOVEL INHIBITORS OF BETA-LACTAMASE | MGAM, MGAM2, PGLS | CYP3A4 1281/4885MAPK1 2975/4885ESR1 3860/4885 |
| US-20100292239-A1 | NOVEL MICROBIOCIDES | CD14, FPR1, MPO | CYP3A4 729/4885MAPK1 2817/4885ESR1 3001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.